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| General Information | |
| Organism | Mus musculus, mouse |
| Cell Line Description | SCC7 is a spontaneously derived squamous cell carcinoma cell line originating from C3H/He mice. In the field of oncology, it serves as a widely utilized syngeneic mouse model, particularly in the study of head and neck squamous cell carcinoma (HNSCC). SCC7 cells exhibit an epithelial morphology characterized by aggressive growth, high tumorigenicity, and the capacity to form solid tumors that recapitulate the microenvironment of human squamous cell carcinoma. This cell line is a preferred model for evaluating the efficacy of radiotherapy, photodynamic therapy (PDT), and immunotherapy. Furthermore, given the well-documented presence of hypoxic regions within large SCC7 tumors, this cell line is extensively employed in the development of hypoxia-targeted prodrugs and in the investigation of tumor angiogenesis mechanisms. |
| Tissue | Skin/Soft tissue |
| Disease | Squamous Cell Carcinoma (SCC) |
| Morphology | Epithelial-like |
| Gender | Not specified (derived from C3H/He mouse) |
| Age | Adult |
| Product Format | Frozen |
| Growth Mode | Adherent |
| Biosafety Level | 1 (Biosafety classification is based on U.S. Public Health Service Guidelines) |
| Applications | 1. Head and neck squamous cell carcinoma (HNSCC) biology research 2. Evaluation of radiotherapy and radio-sensitizing agents 3. Study of tumor hypoxia and microenvironment interactions 4. Screening for novel immunotherapies and cancer vaccines 5. Development of syngeneic solid tumor models in C3H mice |
| Shipped In | Dry ice |
| Storage Temperature | −196°C |
| Characteristics | |
| Tumorigenic | Yes, highly tumorigenic in syngeneic C3H/He mice |
| Hypoxia Profile | Develops significant hypoxic regions in solid tumors in vivo |
| Growth Kinetics | Rapid doubling time both in vitro and in vivo |
| Phenotype | Maintains squamous epithelial characteristics; high transplantability |
| Mycoplasma Test | Negative |
| Culture Conditions and Handling | |
| Subculturing | 1. Remove and discard the culture medium. 2. Briefly rinse the cell monolayer with PBS (Ca²⁺/Mg²⁺-free) to thoroughly remove residual serum. 3. Add 2.0 mL of 0.25% Trypsin-0.53 mM EDTA solution, and observe continuously until the cell monolayer has dispersed (typically takes 3 to 7 minutes). 4. Add complete growth medium to neutralize the trypsin, and gently pipette to prepare a single-cell suspension. 5. Aliquot the cell suspension into new culture vessels. |
| Medium Renewal | 2 to 3 times per week |
| Subcultivation Ratio | A split ratio of 1:4 to 1:10 is recommended |
| Culture Conditions | Atmosphere: Air, 95%; CO2, 5%; Temperature: 37°C |
| Cryopreservation | Complete growth medium supplemented with 5% to 10% (v/v) DMSO |
The above is only part of a part of cell line products. If you don't find the cell line you want, Creative Biogene can also provide stable cell line generation service with the best prices and fastest turnaround time for you! Contact us for more information or to request a quote.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RR00829 | Luciferase Reporter Cell Line - SCC7 | Inquiry |
| CSC-RR01234 | Nluc Reporter Cell Line - SCC7 | Inquiry |
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