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Retroviral vectors are one of the vectors widely used in current gene therapy clinical trials to target pathologies of different origins, such as cancer, genetic diseases or neurological disorders. Creative Biogene has developed scalable retroviral production processes that allow the purification and production of viral vectors with high titer, purity and potency under mild conditions to support and assist clients in the success of subsequent clinical applications of gene therapy.
Creative Biogene's innovative retroviral vector production service platform is quite flexible. To enhance the production process of clinically relevant retroviral vectors for therapeutic applications, our platform integrates a variety of novel and advanced technologies to generate retroviral vectors by transient transfection or by using production cell lines. Our highly efficient HEK293 and HEK293T production cell lines allow rapid insertion of DNA encoding target therapeutic vectors at predetermined optimal chromosomal loci to promote stable and high levels of vector production and consistent production, purification and storage of retroviral vectors. Our optimized processes are designed for various types of retroviral vectors for clinical applications and support high-throughput processes and scale-up.
To meet customer needs for scalable and cost-effective production of retroviruses, Creative Biogene scientists have developed a comprehensive retrovirus production process, using advanced modern tools and technologies from upstream cell culture to downstream purification. The steps of retrovirus production involve the production of cell lines, plasmid transfection, purification methods and various parameters. Our experienced scientists are dedicated to providing comprehensive solutions in all phases of retrovirus production.
Creative Biogene combines our advanced technology and expertise to produce high-quality and pure retroviral vectors for our clients' gene therapy programs. Our controlled process scale-up technologies, along with quality systems and regulatory technologies, meet the requirements of clinical and commercial retroviral vector manufacturing, providing flexible and cost-effective project support. Please feel free to contact us if you have a need, and our experienced specialists will be happy to assist you.
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