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Protein kinases regulate diverse cellular functions through the orchestrated propagation and amplification of cellular stimuli into distinct biological responses by coordinated signal transduction cascades. With several hundred kinases encoded in the human genome, almost every signal transduction process is influenced through interconnected phosphorylation events. Deregulation of kinase activity has been implicated in various diseases, ranging from inflammatory diseases and vascular disorders to neurological disorders and cancer. In the past two decades, protein kinases have emerged as prominent drug targets which are being perused by pharma and academia. Previously thought to be nondruggable, presently more than 40 kinase inhibitors, including antibodies and small molecules, have been approved by the US FDA.
Kinases have established themselves as bona fide therapeutic targets for drug development, as evidenced in the increasing number of FDA-approved agents and the paradigm shift in solid cancer therapy toward small molecule or antibody-based kinase inhibitors. While the development of kinase inhibitors is still mainly concentrated in the field of oncology, a large number of kinase-targeting candidate therapeutics have entered various stages of clinical evaluation for CNS indications. It is noteworthy to mention the increasing trend of academic institutions as the drivers of CNS-targeting kinase inhibitor drug discovery efforts. A holistic method toward assessment of drug-likeness properties affecting overall brain penetrance has been useful in prioritizing lead candidates.
Owing to the complex array of neuroreceptors and subsequent downstream signaling pathways, it is likely that kinases will constitute a major drug target for CNS indications. As a global leader in drug discovery industry, Creative Biogene can offer a variety of kinase-related products including stable cell lines, viral particles and clones for your drug discovery projects in CNS diseases.
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