Creative Biogene is a biotechnology company which has the expertise to provide you with Acetyltransferase Screening and Profiling services.
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Creative Biogene is a biotechnology company which has the expertise to provide you with Acetyltransferase Screening and Profiling services. Creative Biogene’s top priorities are to streamline the platform processes or work with you to design a process that meets your specific needs and accelerate your drug discovery program.
Creative Biogene offers a rapid, flexible profiling and screening service for potential drug inhibitors of histone acetyltransferases (HATs), including small molecules, peptides, and antibodies. Creative Biogene provides two assay platforms, radioisotope based assays and fluorogenic based functional assays. These two highly sensitive and highly reproducible assays can quickly identify potential therapeutics, predict potency, and narrow down a large pool of candidates to a much smaller one.
Fig.1 Histone acetylation and deactylation
Acetyltransferase is a type of transferase enzyme that transfers an acetyl group, such as histone acetyltransferases (HATs), choline acetyltransferase, chloramphenicol acetyltransferase and serotonin N-acetyltransferase. Among them, histone acetyltransferases (HATs) are the most important. These enzymes play a critical role in epigenetic regulation of gene expression. Besides, a potential role of HATs in the pathology of cancer, asthma, COPD and viral infection has been described (Dekker FJ et al. 2009). For example, p300 behaves as a classical tumor suppressor gene (Gayther SA et al. 2000); While, GCN5 plays a key role in EGF-mediated gene transcription and provides a target for the downregulation of oncogenic EGF signaling (Cheung P et al. 2000). These results indicate that the HATs might be exploited as anticancer targets and the specific HAT inhibitors might be potential tools for pharmacological research.
Fig.2 Crystal structure of histone acetyltransferase Gcn5 with bound coenzyme A and histone H3 peptide.
With years of professional experience in the HATs field, Creative Biogene can provide you an effective screening approach with high sensitivity, high reproducibility, quick turnaround, and minimum false positives and negatives to identify your compounds. Creative Biogene is a reliable partner that can work with you to accelerate the speed to achieve your research goals.
If you have any special requirements in acetyltransferase screening and profiling, please feel free to contact us at or 1-631-626-9181. We are looking forward to working together with your attractive projects.