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Protein Biology

Revolutionary Advances in High-Throughput Monoclonal Antibody Screening Technology

A new review in Journal of Biological Engineering highlights groundbreaking advancements in high-throughput monoclonal antibody screening, reducing discovery cycles from months to days. With cutting-edge platforms like phage display, single-cell sequencing, and AI integration, researchers can now achieve rapid, precise antibody development at unprecedented scale.

Unraveling Ubiquitination: Top Five Research Directions Transforming Cellular Regulation and Therapeutic Approaches

Merus’ Zenocutuzumab, a HER2/HER3 bispecific antibody, has received FDA accelerated approval for treating advanced pancreatic and lung cancers with NRG1 fusions, marking a breakthrough in cancer treatment. This innovative therapy offers new insights into dynamic signaling regulation and bispecific antibody development.

Protein Lactylation: A New Link between Metabolism and Gene Expression Regulation

In the long journey of life sciences research, scientists have continuously unveiled the mysteries of life activities. Recently, the discovery of a novel post-translational modification (PTM)—protein lactylation—has provided a new perspective on the connection between cellular metabolism and gene expression regulation.

Next-Generation Targeted Therapy Strategies: Design Optimization for ADCs and PDCs

Targeted therapy has shown significant potential in cancer treatment by directly targeting specific molecular markers on tumor cells, significantly improving treatment selectivity and efficacy.

Harnessing Ion Channels as Therapeutic Targets for Viral Infections

Creative Biogene presented to the client about the potential biological mechanisms of mRNA vaccines and their applications in a number of infectious diseases and cancers.

Accelerating Drug Discovery with High-throughput Screening of Ion Channels

Ion channels are a very important membrane protein family involved in a variety of fundamental physiological processes. Their malfunction causes a variety of human diseases. Therefore, ion channels represent a class of attractive drug targets and a class of important off-targets for in vitro pharmacological profiling.

Adaptor Protein Complex Interaction Map in Arabidopsis Identifies P34 as A Common Stability Regulator

Transport and distribution of biomolecules between plant cell endomembrane systems are essential for plant growth and development. Adaptor Protein (AP) is an evolutionarily very conserved class of complexes that are involved in the fine regulation of endosomal transport in plants.

* For research use only. Not intended for any clinical use.
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