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Neurodegenerative Diseases Diagnostic Kits

Neurodegenerative diseases, so called Degenerative nerve diseases is an umbrella term for a range of conditions which primarily affect the neurons in the human brain. Neurodegenerative diseases are caused by the progressive loss of structure or function of neurons in different regions of the nervous system. Many neurodegenerative diseases – including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease – occur as a result of neurodegenerative processes. Such diseases are incurable, resulting in progressive degeneration and/or death of neuron cells.

Creative Biogene is a leading company offering the complete degenerative nerve diseases diagnostic service and products. Many neurodegenerative diseases are caused by genetic mutations, most of which are located in completely unrelated genes. Clear diagnosis with genetic testing is the basis of effective treatment and management for many disorders of the brain and nervous system. Our talented scientists continuously develop many innovative products in molecular diagnostics.

Alzheimer's disease (AD) is the most common type of dementia. This type of dementia usually starts slowly, first affecting the parts of the brain responsible for memory, thinking, and language. Over time, these symptoms worsen up to the point of patients failing to recognize closest relatives and experiencing problems in basic activities of daily living such as dressing or grooming. In addition to the distinctive memory problems, Alzheimer patients develop other symptoms such as changes in reasoning skills, aphasia, apraxia, deficits in visuospatial abilities, and changes in mood and personality.

Neurodegenerative Diseases Diagnostic KitsFig.1 changes in tau protein lead to the disintegration of microtubules in brain cells.

The best-known genetic risk factor is the inheritance of the ε4 allele of the apolipoprotein E (APOE).1 Alleles in the TREM2 gene have been associated with a 3 to 5 times higher risk of developing Alzheimer's disease.2

Parkinson’s is due to the progressive death of certain nerve cells (neurons) in a part of the brain that controls movement become impaired and/or die. This causes a decrease in the synthesis of dopamine, which causes abnormal brain activity involved in the control of movement.

Mutations in some genes, including SNCA, LRRK2 and GBA, have been found to be risk factors for "sporadic" (non-familial) PD. Mutations in the gene LRRK2 are the most common known cause of familial and sporadic PD, accounting for approximately 5% of individuals with a family history of the disease and 3% of sporadic cases.3 A mutation in GBA presents the greatest genetic risk of developing parkinson’s disease.4

Creative Biogene offers several kinds of diagnostic related kits:

Creative Biogene offers several kinds of diagnostic related service: Genetic mutation detection of neurodegenerative diseases.

Neurodegenerative Diseases Diagnostic Kits

Creative Biogene is the premier institution to provide professional and comprehensive degenerative nerve diseases diagnostic service and products. Simply let us know how you want the disease to be detected.

References:

  1. Mahley R W, Weisgraber K H, Huang Y. INAUGURAL ARTICLE by a Recently Elected Academy Member:Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease[J]. Proceedings of the National Academy of Sciences, 2006, 103(15):5644-5651.
  2. Jonsson T, Stefansson H, Stacy S P D, et al. Variant of TREM2 Associated with the Risk of Alzheimer's Disease[J]. New England Journal of Medicine, 2012, 368(2).
  3. Lesage S, Brice A. Parkinson\"s disease: from monogenic forms to genetic susceptibility factors[J]. Human Molecular Genetics, 2009, 18(R1):R48-R59.
  4. Kalia L V, Lang A E. Parkinson's disease.[J]. Lancet, 2015, 386(9996):896-912.

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