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The development of cell lines is the starting step of the chemical manufacturing and CMC phases and is the core of the biomanufacturing process. High yield and quality cell lines provide a solid foundation for a successful biopharmaceutical production process and determine the quality of the final product. Creative Biogene is committed to providing efficient cell line development services based on our extensive experience in cell line development and leveraging our advanced cGMP technology platform. We specialize in providing all services from vector construction to screening of stable and highly expressed cell lines. These cell lines are GMP compliant and can effectively help our customers to successfully develop and produce biologics such as biosimilars, enzymes, cytokines, antibodies, vaccines and other recombinant proteins.
Creative Biogene has advanced technology platforms and strong development capabilities to provide GMP development services for a wide range of cell lines for different bioprocess applications, including but not limited to the following:
We provide comprehensive one-stop solutions for cGMP cell line development from research-grade cell line development, PCB/MCB/WCB/EOPC banking and characterization, upstream/downstream process (USP/DSP) development, all the way up to small/pilot/large-scale production. We could work with multiple host systems including mammalian cells, yeasts, and bacteria.
Creative Biogene's experienced scientific team provides a standardized process for cell line development, with the entire development cycle typically taking 12-18 months. We can meet the individual demands of our clients at any stage of cell line development, thus ensuring successful research cell banks (RCB), master cell banks (MCB) and working cell banks (WCB). Once the cell line development process is complete, we generate high-quality cell libraries that can be used for further process development and optimization, as well as high level production, thus helping our clients save time and obtain high-quality custom cell lines.
| Starting Material | Deliverables | Turnaround Time |
| Gene sequence or plasmid | High expression cell pool (1-5 cells) | 6-7 weeks |
| Gene sequence or plasmid | Monoclonal cell lines (3-6 strains) | 7-8 weeks |
| Gene sequence or plasmid | Master cell bank | 4 weeks |
| Gene sequence or plasmid | Working cell bank | 4 weeks |
| Gene sequence or plasmid | Cell bank stability analysis (60-90 generations) | 10-13 weeks |
| Gene sequence or plasmid | Purified protein | 4-10 weeks |
| Gene sequence or plasmid | Purified antibodies | 4-10 weeks |
Creative Biogene, as a trusted provider of GMP cell line development services, we are committed to providing cost-effective, high-quality and efficient outsourcing solutions to meet any of our clients' demands and priorities in the biologics and drug development pipeline. Please feel free to contact us if you have a need, and our experienced specialists will be happy to assist you.
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