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BNA Oligonucleotides Synthesis Service

Creative Biogene is a leading biotechnology company which has the expertise and ability in providing Bridged Nucleic Acids (BNA) oligonucleotides synthesis service for customers worldwide. Creative Biogene's sophisticated equipments, advanced technologies and highly experienced staffs are available to assist you synthesis your interested BNA oligodeoxynucleotides. Creative Biogene’s goal is to provide you with the most affordable, high-quality BNA oligodeoxynucleotides synthesis service to ensure your satisfaction in a timely and professional manner.

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Fig.1 The sketch of novel bridged nucleic-acid analogue. [1]

A bridged nucleic acid (BNA) is a modified RNA nucleotide, which is sometimes also referred to as constrained or inaccessible RNA molecules. BNA monomers can contain a five-membered, six-membered or even a seven-membered bridged structure with a “fixed” C3’-endo sugar puckering. The bridged structure is synthetically at the 2', 4'-position of the ribose to afford a 2', 4'-BNA monomer. BNA monomers can be easily incorporated into natural oligonucleotide strands and allow the flexibility to design BNA/DNA, BNA/RNA hybrid oligo to accommodate the needs for extremely high and sequence-specific hybridization ability with natural nucleic acids, along with strong nuclease-resistant properties.

As far, a third generation of BNA (2’, 4'-BNA-NC) has been developed. 2’, 4'-BNA-NC contains a 6-membered ring with a N-O bond between the 2'-hydroxyl and the 4'-carbon of the ribose moiety. It exhibits superior binding affinity towards single stranded RNA, a better binding affinity to double stranded DNA and excellent enzymatic stability to nucleases. Thus, it has become a great choice for many biological applications.

With years of development, Creative Biogene is able to provide you with the most affordable, high-quality custom BNA oligodeoxynucleotides synthesis service to best match your specific needs. With our unparalleled expertise and experience in BNA oligodeoxynucleotides synthesis, Creative Biogene should be your first choice for the BNA oligodeoxynucleotides projects.

Applications:

  • Antisense research
  • RNAi research
  • In situ hybridization
  • Real-time PCR and/or other specific PCR
  • FISH
  • Other nucleotide based applications

References:

  1. Abdur Rahman, et al. (2008). Design, Synthesis, and Properties of 2‘, 4‘-BNANC: A Bridged Nucleic Acid Analogue. Journal of the American Chemical Society, 130(14), 4886-4896.
  2. Yamamoto T., et al. (2012). Superior silencing by 2′, 4′-BNANC-based short antisense oligonucleotides compared to 2′, 4′-BNA/LNA-based apolipoprotein B antisense inhibitors.Journal of nucleic acids2012.
  3. Cromwell CR., et al. (2018). Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity. Nature communications9(1), 1448.

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