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MicroRNAs (miRNAs) are a class of short non-coding RNAs whose end product is a functional RNA molecule of 22 nucleotides. They regulate the expression of target genes by binding to complementary regions of transcripts to inhibit their translation or cause mRNA degradation. The mechanisms of miRNA-mediated gene regulation are conserved from plants to humans, and miRNAs are encoded by respective genes. Like other regulatory molecules, the expression levels of miRNAs frequently change due to a variety of physiological processes such as development, immune response, metabolism, and disease, as well as toxicological outcomes. Accumulating evidence indicates that miRNAs are frequently overexpressed or downregulated by cancer, inflammation, obesity, diabetes, neurological, cardiovascular or autoimmune diseases.
The rat genome is similar to that of humans, making rats a valuable organism for studying human disease. The rat developed a variety of cancers, including breast and prostate cancers. Currently, more than 400 miRNAs have been identified in rats. miRNA regulation has been shown to play a crucial role in cancer initiation and progression, making it an important focus of research. Likewise, neurological diseases such as Parkinson's, Alzheimer's and Huntington's can also be modeled in rats.
The development of cell lines that overexpress specific miRNAs is invaluable for studying the role of miRNAs in cancer and for developing miRNA-based therapeutics. Rat miRNA overexpressing cell lines can be generated by transfecting target cells with a plasmid or virus containing the desired miRNA sequence. These cell lines can be used to study the effects of miRNAs on cellular processes such as proliferation, migration, and differentiation.
Creative Biogene is developing stable cell lines that overexpress the rat miRNA precursors covered in the current miR library. Our rat miRNA overexpression stable cell lines are constructed by lentiviral transduction or non-viral plasmid transfection vectors, optimized by our scientists to allow miRNA expression and maturation in cells.
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