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Gene Mutagenesis Service

Creative Biogene is a leading biotechnology company which has the expertise in providing gene mutagenesis service for customers. Creative Biogene's sophisticated equipments, advanced technologies and highly experienced staffs are available to provide you with the complete mutagenesis service, including creating single or multiple point mutations, deletions, insertions or random mutations into any target gene. Using fast and efficient mutagenesis methods, Creative Biogene can quickly create novel constructs for large or small projects.

Mutagenesis in the laboratory is an important molecular biology technique that is used to make specific and intentional changes to the DNA sequence of a gene and any gene products. It is used for investigating the structure and biological activity of DNA, RNA, and protein molecules, or for protein engineering. With years of experience in mutagenesis field, Creative Biogene can offer the most affordable and high-quality gene mutagenesis service to meet your various needs.

Creative Biogene is able to provide the following gene mutagenesis service for your scientific research:

Site-Directed Mutagenesis

Creative Biogene uses a targeted PCR-based process to introduce genetic variation precisely, and then clone the construct into the vector of your choice. Creative Biogene's site-directed mutagenesis services include point mutations, deletions, and insertions. Creative Biogene's site-directed mutagenesis services can provide you a fast, cost-saving way to get 100% accurate mutant DNA clones.

Random Mutagenesis

Creative Biogene uses the error-prone PCR technique to introduce mutations into a gene, result in amino acid substitutions in proteins. The mutated PCR products are cloned into the specific vector of your choice. Creative Biogene can generate 1 to 4 random amino acid substitutions per 1,000bp. And the randomized portion of the gene can cover the complete open reading frame or your desired regions of the gene. Creative Biogene can offer the most affordable and fastest random mutagenesis service for your scientific research.


  1. Zoller MJ (1991). New molecular biology methods for protein engineering. Curr Opin Biotechnol, 2(4): 526–531.
  2. Reikofski J and Tao BY (1992). Polymerase chain reaction (PCR) techniques for site-directed mutagenesis. Biotechnol Adv, 10(4): 535–547.
  3. Wilson DS and Keefe AD (2001). Random mutagenesis by PCR. Curr Protoc Mol Biol.Chapter 8:Unit8.3

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