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The cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling systems are one of the earliest discovered signal transduction systems and are involved in various physiological processes such as cell proliferation and differentiation, cell cycle regulation, gene expression, inflammation and metabolism function. By catalyzing the hydrolysis of cAMP and cGMP, phosphodiesterases (PDEs) regulate their intracellular concentrations and thus their diverse biological effects. It is now clear that any single cell type can express different PDEs and that PDE localization is a major factor in regulating cAMP or cGMP cellular function.
Figure 1. Schematic structure of PDE enzymes. (Bondarev A D, et al. 2022)
Cyclic nucleotide PDEs are a diverse superfamily consisting of 11 families, encoded by 21 genes, and are responsible for catalyzing the hydrolysis of the 3'-cyclic phosphate bond in cyclic nucleotide molecules. The biological functions of individual families are diverse and include involvement in processes such as myocyte contractility, male and female sex cell development and function, steroidogenesis, inflammatory cell activation, or neuronal signaling. Many reviews indicate the impact of PDE-mediated disease on cancer, inflammation, neurological diseases, pulmonary disease, and cardiovascular disease, among others. To date, global efforts to develop PDE enzymes therapeutically have yielded a large number of molecules with varying selectivities and therapeutic applications, as well as an increasing number of drugs in development.
Stable cell lines are important tools for drug screening, gene function studies, or protein production. Stable cell lines represent a homogeneous population, generated from selected clones, and maintain stable expression of the target protein over generations. Creative Biogene has proven its success in the generation and validation of stable cell lines to accelerate your novel drug discoveries and biomedical research. Fully-validated, we have generated a unique collection of PDE stable cell lines to provide powerful assay platforms for all research projects.
Please browse our PDE stable cell lines collection to find your desired one.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RG1628 | Human PDE1B Stable Cell Line-CHO-CNG-sGC | Inquiry |
| CSC-SC011497 | Panoply™ Human PDE1A Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011498 | Panoply™ Human PDE1B Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011499 | Panoply™ Human PDE1C Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011501 | Panoply™ Human PDE3A Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011502 | Panoply™ Human PDE3B Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011503 | Panoply™ Human PDE4A Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011504 | Panoply™ Human PDE4B Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011505 | Panoply™ Human PDE4C Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011506 | Panoply™ Human PDE4D Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011508 | Panoply™ Human PDE5A Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011512 | Panoply™ Human PDE6D Over-expressing Stable Cell Line | Inquiry |
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