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Kinases belong to the family of phosphotransferases and play critical roles in the process known as phosphorylation in which a phosphorylated substrate and ADP are produced. On the basis of the substrate kinases act upon, they can be generally classified into three groups: protein kinases, lipid kinases and carbohydrate kinases. The phosphorylation state of a molecule controlled by a specific kinase can modulate its activities or interactions with other molecules in response to an external stimulus.
Kinases are associated with many complex cellular pathways including cell metabolism, cell signaling, cell transport etc., which makes them very important to human physiology. Since many kinases can enhance cell proliferation, cell migration and cell survival, loss-of-function or gain-of-function mutations in kinases can lead to various types of cancer and some human disorders in immune, neurological and infectious diseases.
Because of their important cellular functions, kinases have become important drug targets in drug discovery and development for the treatment of human diseases especially diverse cancers. These targets include epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), erb-b2 receptor tyrosine kinase 2 (ERBB2), platelet-derived growth factor receptor (PDGFR), Kit, ABL, SRC, mTOR and so on. Small-molecule kinase inhibitors against these targets have shown prominent roles in the treatment of many cancers.
With decades of experience in cell line engineering and drug discovery, Creative Biogene has developed a large collection of kinase stable cell lines that can be used for in vitro cell-based kinase assays. The use of these cell lines allows for broad set of assays and reduced assay development time.