RNA

An In-Depth Overview of Aptamers

nucleic acid aptamers have become an important class of synthetic ligands with broad potential across biomedical research and therapeutic development. Derived entirely through in vitro selection, these single-stranded oligonucleotides can fold into defined three-dimensional structures that enable high-affinity and high-specificity binding to a wide range of molecular targets. Continuous refinements in SELEX methodology, coupled with advances in chemical modification and screening technologies, have transformed aptamer research from a conceptual framework into practical biomedical applications.

RNA Editing: From Laboratory to Clinical Mainstay

RNA editing, as a precise and reversible gene modification technology that does not introduce DNA double-strand breaks, is emerging as an important branch of RNA-based therapeutics. Unlike conventional strategies such as mRNA vaccines, siRNA, or antisense oligonucleotides that primarily alter the expression level of gene products, RNA editing directly corrects single nucleotides on RNA molecules, enabling precise restoration or modification of protein function at the transcript level. With the rapid development of novel editing enzymes, delivery systems, and target design strategies, RNA editing is transitioning from basic research to clinical exploration, showing unique potential in treating rare genetic disorders, neurodegenerative diseases, and certain metabolic conditions.

Lipid Nanoparticles (LNPs) in RNA Therapeutics: Transforming mRNA Vaccines, Cancer Immunotherapy, and CRISPR Delivery

In recent years, a once-obscure drug delivery technology has risen to prominence—lipid nanoparticles (LNPs). From mRNA vaccines and cancer immunotherapy to cutting-edge gene editing, LNPs are redefining the landscape of modern medicine.

The Breakthrough Potential of Oligonucleotide Drugs

Oligonucleotide drugs are short sequences of nucleotides designed to interact with specific target molecules within cellular pathways. These drugs include antisense oligonucleotides, small interfering RNAs, microRNA, and aptamers.

Revolutionary Innovations in Lipid Nanoparticles (LNPs) for In Vivo RNA Delivery and Prospective Applications

Creative Biogene introduced customers to the fundamental aspects of LNP and its application in the development of novel RNA therapeutics.

Cas 9 mRNA for Precision Gene Editing

Creative Biogene introduced customers to the application of Cas9 mRNA for gene editing and its potential for the future of genetic engineering.

Unlocking the Potential of Bioconjugation Enhancing Oligonucleotide Delivery

The delivery potential of oligonucleotides can be enhanced through direct covalent conjugation of various moieties that promote intracellular uptake, target the drug to specific cells/tissues or reduce clearance from the circulation. These include lipids (for example, cholesterol that facilitates interactions with lipoprotein particles in the circulation), peptides (for cell targeting and/or cell penetration), α-tocopherol, aptamers, antibodies, fatty acids and sugars (for example, N-acetylgalactosamine (GalNAc)).

The Rise of Circular RNA Therapeutics: Exploring Current Strategies and Overcoming Challenges

Significant progress has been made in circular RNA (circRNA) research in recent years. Increasing evidence suggests that circRNAs play important roles in many cellular processes, and their dysregulation is implicated in the pathogenesis of various diseases.

Lipid Nanoparticles as Promising RNA Delivery Vehicles

RNA-based therapeutics are one of the most attractive classes of drugs for treating a variety of diseases. To function in vivo, RNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and RNA release.

Decoding the Synthesis of CircRNA: In Vitro Breakthroughs

Circular RNA (circRNA) is a unique type of noncoding RNA molecule. Compared with traditional linear RNA, circRNA is a covalently closed circle produced by a process called backsplicing. CircRNA is abundant in many cells and has rich functions in cells, such as acting as miRNA sponge, protein sponge, protein scaffold, and mRNA regulator.

* For research use only. Not intended for any clinical use.

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