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| General Information | |
| Organism | Homo sapiens, human |
| Cell Line Description | SU-DHL-4 is a lymphoblastoid cell isolated from the peritoneal effusion of a 38-year-old Caucasian male patient. This cell line represents a model for diffuse large B-cell lymphoma (DLBCL), one of the most common types of non-Hodgkin lymphoma in adults. The SU-DHL-4 cell line has a translocation of chromosomes 14 and 18. There is a major rearrangement in the BCL-2 gene. These cells express several key immunophenotypic markers associated with the B-cell lineage, such as CD19 and CD20, which are essential for the development and function of B lymphocytes. These markers also make SU-DHL-4 an excellent target for testing B-cell specific therapies, including monoclonal antibodies and small molecule inhibitors that disrupt key signaling pathways involved in lymphoma cell survival and proliferation. |
| Tissue | Peritoneal effusion |
| Disease | Diffuse large B-cell lymphoma |
| Morphology | Lymphoblast-like |
| Gender | Male |
| Age | 38 years |
| Product Format | Frozen |
| Growth Mode | Suspension |
| Biosafety Level | 1 Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Applications | 1. Cancer Biology Studies 2. Drug Discovery and Development 3. Genomic and Epigenomic Research 4. Immunotherapy Research |
| Shipped In | Dry ice |
| Storage Temperature | −196°C |
| Additional Info | The SU-DHL-4 cell line is negative for Candida uptake. It has been shown that the cells are negative for Epstein-Barr virus (EBV). |
| Characteristics | |
| Immunology | CD3 -, CD10 +, CD13 -, CD19 +, CD20 +, CD34 -, CD37 +, CD38 +, cyCD79a +, CD138 -, HLA-DR +, sm/cyIgG +, sm/cyIgM -, sm/cykappa +, sm/cylambda - |
| Genes Expressed | IgG+; IgA-; IgD-; Kappa+; IgM-; Lambda-; This cell line has relatively high expression levels of Bax; Bak; AIF; high caspase-9 activity. |
| Mycoplasma Test | Negative |
| Culture Conditions and Handling | |
| Subculturing | Maintain the culture by regularly adding or replacing the medium. Start the culture at 2 x 10^5 cells/mL and maintain the cell concentration in the range of 1 x 10^5 to 1 x 10^6 cells/mL for optimal growth. |
| Medium Renewal | Every 2 to 4 days. |
| Subcultivation Ratio | The ratio of 1:2 to 1:6 is recommended. |
| Culture Medium | 80-90% RPMI 1640 + 10-20% FBS |
| Culture Conditions | Atmosphere: Air, 95%; CO2, 5%; Temperature: 37℃ |
| Cryopreservation | Frozen with 70% medium, 20% FBS, 10% DMSO |
The above is only part of a part of cell line products. If you don't find the cell line you want, Creative Biogene can also provide stable cell line generation service with the best prices and fastest turnaround time for you! Contact us for more information or to request a quote.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RO01223 | Cas9 Stable Cell Line - SU-DHL-4 | Inquiry |
| CSC-RR0600 | GFP Reporter Cell Line - SU-DHL-4 | Inquiry |
| CSC-RR0601 | Luciferase Reporter Cell Line - SU-DHL-4 | Inquiry |
| CSC-RR0602 | GFP/Luc Reporter Cell Line - SU-DHL-4 | Inquiry |
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