AI-Antibody Engineering Fusion

Creative Biogene is a leading biotechnology company specializing in providing comprehensive gene, protein, and cell engineering solutions. With over a decade of experience and a global reach spanning more than 40 countries, we have supported over 1,000 studies and facilitated the successful publication of more than 300 papers. Our antibody protein solutions offer significant advantages, including efficient antibody screening, optimization, and production services. We ensure quick feedback and short turnaround times, guaranteeing both efficiency and reliability. Trust Creative Biogene for unparalleled precision and results.

Overview of Antibody-Drug Development

Antibodies, generated in response to antigens, are essential proteins that the immune system uses to identify and neutralize viruses and other foreign substances. Renowned for their precise binding capabilities, antibodies are pivotal in both research and clinical therapy. The field of antibody drugs has seen rapid growth within biopharmaceuticals, expanding therapeutic applications and driving medical advancements.

However, the market now faces saturation, prompting researchers to explore next-generation technologies like bispecific antibodies (BsAbs), antibody-drug conjugates (ADCs), and antibody-nucleic acid conjugates (ANACs) for innovative medical solutions. These technologies have also raised the bar for antibody drug development. So how do we inspire and aid research in next-generation antibody drugs? How can we efficiently design the next generation of antibody drugs?

Revolutionize Antibody Discovery and Development with Creative Biogene's AI-Driven Solutions

Precision Epitope Targeting, Feasibility Enhancement, and Rapid Structural Analysis, All at Your Fingertips!

Under our AI-Antibody Engineering Fusion initiative, Creative Biogene's AI-Assisted Drug Design Platform is dedicated to overcoming the challenges in contemporary antibody engineering. Our platform offers clients efficient and reliable solutions for antibody drug design, accelerating the development process, mitigating risks, and providing robust support for developing and commercializing novel therapeutics.

Challenge 1: Epitope Targeting

Screening methods such as immunization or directed evolution still encounter difficulty in identifying specific or optimal epitopes on target antigens.

Our AI-driven antibody engineering solution accurately predicts antibody-antigen binding sites, facilitating the swift identification of specific or optimal epitopes on target antigens.

Challenge 2: Developmental Feasibility

Most initial candidate antibody binders obtained through screening may exhibit poor developmental feasibility, resulting in high failure rates during subsequent development.

Our approach integrates deep learning and molecular dynamics simulations. Improved prediction and sampling enhance antibody structures and properties, guiding redesign and reducing failure rates in development.

Challenge 3: Structural Analysis

Reliance on methods such as X-ray crystallography or nuclear magnetic resonance (NMR) is often time-consuming and low-throughput, posing engineering challenges.

By integrating machine learning with molecular dynamics, our innovative technologies transform the landscape of biologics drug design. They elevate protein structure exploration, optimization, and prediction, resulting in substantial enhancements in efficiency and accuracy.

Core Service Offerings

Antibody Drug Design

Creative Biogene provides comprehensive AI-driven antibody drug design services to accurately predict antibody structure, optimize affinity and target specificity, and predict biological efficacy. Through sequence generation, library construction, screening, experimental verification, and other links, we have improved the efficiency and success rate of antibody drug development.

Characterization of Antibody Properties

By integrating deep learning and physical or structural databases, we can advance drug discovery efforts by accurately predicting properties such as immunogenicity, aggregation, viscosity, and half-life of antibodies.

Antibody Structure Prediction and Optimization

Our service comprehensively uses AI technology to refine the Fc region and eliminate PTM sites to optimize the antibody structure. This comprehensive strategy guarantees superior antibody stability and performance, effectively supporting your research.

Antibody-Antigen Dynamic Simulation

We model antibody-antigen interactions, refine antibody design, and validate efficacy. Integrating protein interaction databases like BioGRID, enhances prediction accuracy, accelerating access to vital data and improving the success of antibody development projects.

Advantages of Our Antibody-Related Services

Closed-loop Validation: Our AI integration enables seamless validation between dry-lab predictions and wet-lab experiments, ensuring a closed-loop verification process for enhanced reliability and efficiency.
Advanced AI Integration: Our platform seamlessly integrates cutting-edge AI technologies, enhancing antibody engineering processes from epitope targeting to structural analysis.
Predictive Accuracy: Leveraging deep learning and molecular dynamics simulations, we achieve unparalleled predictive accuracy in antibody structure, epitope targeting, and property characterization.
Efficiency Enhancement: By automating tedious tasks and streamlining workflows, our platform accelerates antibody drug design processes, reducing development timelines and costs.
Risk Mitigation: Through thorough wet experiment validation and data-driven insights, we mitigate risks associated with antibody development, ensuring robustness and reliability.
Comprehensive Solutions: From antigen binding affinity optimization to antibody structure optimization, our platform offers a full spectrum of services tailored to meet diverse client needs in antibody engineering.

Contact Us

For more information about our AI-Antibody Engineering Fusion initiative and how Creative Biogene can support your research and development needs, please visit our website or contact our team of experts today.

* For research use only. Not intended for any clinical use.

Quick Inquiry