Creative Biogene is a world leader in the area of virus engineering and packaging.
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Creative Biogene is a world leader in the area of virus engineering and packaging. With the deep knowledge on the genetics and molecular biology of HSV, along with our state-of-the-art facilities, scientists at Creative Biogene have developed an excellent HSV production platform.
Herpes simplex virus (HSV) is an enveloped, large linear and double-stranded DNA (~150 kb) virus in the family Herpesviridae. There are two HSV species: Herpes Simplex Virus Type I (HSV-1) and Herpes Simplex Virus Type II (HSV-2), both of which can infect humans and cause diseases. HSV genome replicates by means of a rolling circle mechanism which forms head-to-tail concatamers. In the large genome of HSV, about half of the sequences are non-essential genes, which means they can be replaced with one or multiple transgenes.
Figure 1. Herpes simplex virus type 1 genome
HSV-1 has been well-characterized and engineered as a gene delivery vector both in research and therapy. Three classes of recombinant vectors have been developed based on HSV-1, which include replication-competent viruses, replication-defective viruses and amplicons. The HSV system we have established is based on HSV-1 H129 strain which is originally isolated from a patient. Through genetic engineering and optimization, our HSV system are able to produce high titer viruses allowing high level transgene expression in infected host cells.
Figure 2. Fluorescent image of cells infected with rHSV1-EGFP
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