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The development and approvals of targeted drugs have improved treatment outcomes of patients with NSCLC harboring driver mutations. This progress in oncology is encouraging; however, mechanistic analyses of acquired resistance to these targeted drugs is necessary to further improve patient outcomes.
Cytotoxic T cells play a central role in immune-mediated control of cancer, infectious diseases, and autoimmunity. Genome-scale CRISPR screens in primary human T cells would enable comprehensive target discovery studies that could be rapidly translated into new immunotherapies with small molecules, biologics, and gene-engineered adoptive cell therapies.
Programmed cell death is regulated by the balance between activating and inhibitory signals. RECS1 is a member of the evolutionarily conserved TMBIM superfamily and, more specifically, the LFG family of cell death regulators. Although the role of these proteins as inhibitors of cell death is well documented, the possible existence of proapoptotic members remained elusive.
This article describes the unique advantages of CAR-NK cells, their production and application in cancer cell immunotherapy.
The HEK293 cell line was established by transforming human embryonic kidney cells with sheared adenovirus type 5 DNA. Since then, many subtypes and derivatives have been established, with HEK293, HEK293-T, and HEK293-F frequently used in the production of biopharmaceuticals.
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