Custom mRNA Synthesis Service

Creative Biogene, as one of the leading biotechnology companies, can offer the dedicated service for the production of high quality mRNAs. With the help of our highly experienced staffs, Creative Biogene is able to synthesis custom mRNAs at microgram to multigram scales, with lengths ranging from a few hundred nucleotides to kilobases. Creative Biogene's goal is to provide you with the most affordable, high-quality custom mRNA synthesis service to ensure your satisfaction in a timely and professional manner.

Fig.1 Preparation of synthetic mRNA by in vitro transcription (IVT). [2]

Synthetic mRNA has received much attention due to their therapeutic potential in the fields of gene therapy and regenerative medicine. With the development of in vitro transcription (IVT) methods, synthetic mRNA has become an emerging class of gene therapy. Desired proteins can be produced in cells by exogenous delivery of IVT mRNA, which does not integrate into the host genome and results in transient production of target proteins. Due to the simpler intracellular process for protein expression, the risk of mutation and tumor development is minimized. Therefore, the use of IVT mRNA is especially attractive for applications in regenerative medicine, vaccination, the treatment of hereditary diseases and tumors, and cell engineering. In addition, these in vitro transcripts could also be used in analytical techniques (e.g. hybridization analysis), structural studies (for NMR and X-ray crystallography), in biochemical and genetic studies (e.g. as antisense reagents), and as functional molecules (ribozymes and aptamers).

Creative Biogene has years of professional and abundant experience which can provide custom mRNA synthesis from plasmid-based template by in vitro transcription. Our mRNA services allow researchers to tailor synthesis and introduce modifications to produce transcripts which are optimal for downstream applications. Creative Biogene is confident in providing you with the most affordable, high-quality custom mRNA synthesis service in a short turnaround time. If you have any special requirements in our custom mRNA synthesis service, please feel free to contact us. We are looking forward to working together with your attractive projects.

Features:

ARCA Cap and poly-A tailed incorporated
Modified nucleotides available (upon request)
Flexible production scale
Competitive prices and fast turnaround time

References:

Steinle H, et al. (2017). Concise review: application of in vitro transcribed messenger RNA for cellular engineering and reprogramming: progress and challenges. Stem Cells, 35(1), 68-79.
Kwon H, et al. (2018). Emergence of synthetic mRNA: in vitro synthesis of mRNA and its applications in regenerative medicine. Biomaterials, 156, 172-193.
Beckert B & Masquida B. (2011). Synthesis of RNA by in vitro transcription. In Rna (pp. 29-41). Humana Press.

* For research use only. Not intended for any clinical use.

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