Email:

CBpromise   

Our promise to you:
Guaranteed product quality, expert customer support.

24x7 CUSTOMER SERVICE
CONTACT US TO ORDER

Recombinase AAV Particles

Recombinases including Cas9 recombinase, AsCpf1 recombinase, Cre recombinase and optimized FLP recombinase (FLPo), can cause excision/insertion, inversion, translocation and cassette exchange, and are widely used in manipulating the structure of cell genomes.

CRISPR (clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found within the genomes. Cas9 (CRISPR-associated protein 9) is a nuclease that can recognize and cleave specific strands of DNA guided by CRISPR sequences. CRISPR-Cas9 technology plays a wide variety of applications in basic biological research, development of biotechnology products, and treatment of diseases.

AsCpf1, a member of the Cpf1 nuclease family, is an alternative nuclease to Cas9 for CRISPR mediated and has been proved to generate efficient genome editing in mammalian cells.

Cre-lox and Flp-FRT systems are popular and powerful site-specific-recombinase (SSR) tools in genome editing.

Cre recombinase, a Type I topoisomerase from P1 bacteriophage, catalyzes site-specific recombination of DNA between loxP sites. loxP is a 34 bp DNA sequence at which confers directionality. The orientation and location of introduced loxP sites allow for Cre-mediated gene translocation, inversion, or deletion. The bacteriophage P1 Cre/loxP system has proven to be a powerful tool to manipulate gene expression in vivo using transgenic mice expressing Cre recombinase under the control of specific promoters, or local viral delivery of Cre-encoding constructs.

Based on the Cre-lox recombination principles, scientists have developed constructs to activate/inactivate genes when Cre is present. By expressing Cre at specific times or locations, you can precisely control the expression of your gene of interest. Many Cre constructs also contain fluorescent labels that indicate if recombination has occurred, allowing for direct comparison of Cre- and Cre+ cells. Recombinant adeno-associated viruses (rAAVs) are often used as vehicles for in vivo gene transfer. Currently, methods that combine Cre-knockin mice and Cre-activated AAV have been developed to achieve high-level, stable, and cell-type-specific gene expression.

The FLP-FRT system is similar to the Cre-lox system and has been widely used for generating conditional knockout mice. FLP recombinase recognizes FRT sequences flanking a genomic region of interest. FLPo is a codon optimized FLP that possesses higher FRT recombination efficiency for both in vivo and in vitro in mouse.

As a leader in AAV technology, Creative Biogene has a wide variety of recombinase AAV particles. These viral particles undergo quality control, including AAV titering, confirmation of the transfer plasmid with PCR, and purity assessment. Please click on the AAV particles below to find the product of interest. If you have any special requirements, please feel free to contact us.

Browse All Recombinase AAV Particles

Cat.No. Product Name Price
AAV00134ZAAV1-Syn-FLPoInquiry
AAV00234ZAAV DJ/8-CreInquiry
AAV00252ZAAV DJ-Syn-CreInquiry
AAV00259ZAAV9-CAG-Cre-GFPInquiry
AAV00269ZAAV9-CMV-iCreInquiry
AAV00135ZAAV1-CMV-FLPoInquiry
AAV00169ZAAV2-Syn-CreInquiry
AAV00189ZAAV5-CAG-FLPoInquiry
AAV00199ZscAAV6-CreInquiry
AAV00209ZAAV6-CAG-FLPoInquiry
AAV00129ZAAV1-CAG-FLPoInquiry
AAV00154ZscAAV2-CreInquiry
AAV00188ZAAV5-Syn-FLPoInquiry
AAV00222ZAAV8-CMV-iCreInquiry
AAV00248ZAAV DJ-Cre-GFPInquiry
AAV00256ZscAAV9-CreInquiry
AAV00064ZCre-GFP Adeno-associated virus(AAV Serotype 6)Inquiry
AAV00048ZCre Adeno-associated virus(AAV Serotype 9)Inquiry
AAV00131ZAAV1-CAG-iCreInquiry
AAV00163ZAAV2-CMV-hAsCpf1Inquiry
AAV00262ZAAV9-Syn-Cre-GFPInquiry
AAV00267ZAAV9-CAG-FLPoInquiry
AAV00297ZAAV PHP.B-CreInquiry
AAV00044ZCre Adeno-associated virus(AAV Serotype 1)Inquiry
AAV00167ZAAV2-Syn-FLPoInquiry
AAV00217ZAAV8-Syn-CreInquiry
AAV00127ZAAV1-CMV-saCas9-U6-sgRNAInquiry
AAV00157ZAAV2-CAG-Cre-GFPInquiry
AAV00172ZAAV3-CreInquiry
AAV00174ZAAV3-Cre-GFPInquiry
AAV00207ZAAV6-Syn-iCreInquiry
AAV00246ZAAV DJ-CreInquiry
AAV00261ZAAV9-Syn-CreInquiry
AAV00061ZCre-GFP Adeno-associated virus(AAV Serotype 1)Inquiry
AAV00100ZSynapsin-Cre-GFP AAV (Serotype 8)Inquiry
AAV00180ZAAV4-Cre-GFPInquiry
AAV00187ZAAV5-Syn-iCreInquiry
AAV00206ZAAV6-CMV-iCreInquiry
AAV00221ZAAV8-CAG-FLPoInquiry
AAV00307ZAAV PHP.eB-CAG-Cre-GFPInquiry
AAV00046ZCre Adeno-associated virus(AAV Serotype 6)Inquiry
AAV00210ZAAV6-CMV-FLPoInquiry
AAV00220ZAAV8-CAG-iCreInquiry
AAV00225ZAAV8-CMV-FLPoInquiry
AAV00235ZscAAV DJ/8-CreInquiry
AAV00240ZAAV DJ/8-Syn-CreInquiry
AAV00045ZCre Adeno-associated virus(AAV Serotype 2)Inquiry
AAV00132ZAAV1-Syn-iCreInquiry
AAV00165ZAAV2-CMV-iCreInquiry
AAV00166ZAAV2-Syn-iCreInquiry
AAV00200ZAAV6-CAG-CreInquiry
AAV00268ZAAV9-CAG-iCreInquiry
AAV00065ZCre-GFP Adeno-associated virus(AAV Serotype 8)Inquiry
AAV00125ZAAV1-CAG-Cre-mCherryInquiry
AAV00130ZAAV1-CMV-iCreInquiry
AAV00164ZAAV2-CAG-FLPoInquiry
AAV00204ZAAV6-CAG-iCreInquiry
AAV00219ZAAV8-ApoE/AAT1-CreInquiry
AAV00236ZAAV DJ/8-Cre-GFPInquiry
AAV00266ZAAV9-αMHC-CreInquiry
AAV00283ZAAV9-TRE-CreInquiry
AAV00313ZAAV PHP.S-CAG-CreInquiry
AAV00020ZCre Adeno-associated virus(AAV Serotype 5)Inquiry
AAV00111ZAAV9-CMV-Cas9Inquiry
AAV00128ZAAV1-CMV-AsCpf1Inquiry
AAV00179ZscAAV4-CreInquiry
AAV00247ZscAAV DJ-CreInquiry
AAV00306ZAAV PHP.eB-CAG-CreInquiry
AAV00315ZAAV PHP.S-Syn-CreInquiry
AAV00168ZAAV2-CMV-FLPoInquiry
AAV00178ZAAV4-CreInquiry
AAV00183ZscAAV5-CreInquiry
AAV00208ZAAV6-Syn-FLPoInquiry
AAV00215ZscAAV8-CreInquiry
AAV00272ZAAV9-Syn-FLPoInquiry
AAV00066ZCre-GFP Adeno-associated virus(AAV Serotype 9)Inquiry
AAV00123ZscAAV1-CreInquiry
AAV00311ZAAV PHP.S-CMV-CreInquiry
AAV00047ZCre Adeno-associated virus(AAV Serotype 8)Inquiry
AAV00162ZAAV2-CAG-iCreInquiry
AAV00224ZAAV8-Syn-FLPoInquiry
AAV00258ZAAV9-CAG-CreInquiry
AAV00271ZAAV9-Syn-iCreInquiry
AAV00298ZAAV PHP.B-Cre-GFPInquiry
AAV00063ZCre-GFP Adeno-associated virus(AAV Serotype 5)Inquiry
AAV00062ZCre-GFP Adeno-associated virus(AAV Serotype 2)Inquiry
AAV00186ZAAV5-CMV-iCreInquiry
AAV00205ZAAV6-CAG-Cre-GFPInquiry
AAV00223ZAAV8-Syn-iCreInquiry
AAV00264ZAAV9-CMV-saCas9-U6-sgRNAInquiry
AAV00273ZAAV9-CMV-FLPoInquiry
AAV00291ZAAV9-Syn-Cre-GFPInquiry
AAV00136ZAAV1-Syn-CreInquiry
AAV00156ZAAV2-CAG-CreInquiry
AAV00173ZscAAV3-CreInquiry
AAV00190ZAAV5-CMV-FLPoInquiry
AAV00304ZAAV PHP.eB-CMV-CreInquiry
AAV00309ZAAV PHP.eB-Syn-CreInquiry
For research use only. Not intended for any clinical use.