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Antisense Oligonucleotides Synthesis Service

Creative Biogene is a leading biotechnology company specializing in custom antisense oligonucleotides synthesis service. Creative Biogene's sophisticated equipment, advanced technologies and highly experienced staffs are available to provide you with the comprehensive antisense oligonucleotides synthesis service, such as flexible synthesis scale, comprehensive oligonucleotides backbones, and modifications. Creative Biogene’s goal is to provide you with the most affordable, high-quality antisense oligonucleotides synthesis service to ensure your satisfaction in a timely and professional manner.

Antisense oligonucleotide (ASO) mechanisms of action. Fig.1 Antisense oligonucleotide (ASO) mechanisms of action. [3]

Antisense oligonucleotides (ASOs) are short (usually 15-25 nt), synthetic, single-stranded DNA oligos that are designed to specifically bind to a target messenger RNA (mRNA) by Watson–Crick hybridization, inducing selective degradation of the mRNA or prohibiting translation of the selected mRNA into protein. The hybridization of the ASO and a target mRNA depends on design and chemistry modification, which may result in selective degradation by endogenous nucleases, or alternatively, inhibition of the processing and/or function of the mRNA by an occupancy-only mechanism. ASO technology provided an oligonucleotide-based approach to disrupting gene expression and has become effective tools in basic molecular biology, and proteomics research, often used for target screening and validation as well as for drug discovery.

As one of the leading biotechnology company in the world, Creative Biogene possesses extensive expertise and experience which is able to provide you custom antisense oligonucleotide synthesis service. Creative Biogene’s top priorities are to streamline the platform processes or work with you to design a process that meets your specific needs. Creative Biogene is confident in providing you with the most affordable, high-quality custom antisense oligonucleotide synthesis service in a short turnaround time.

Features of Creative Biogene’s custom antisense oligonucleotide synthesis service:

  • Comprehensive backbones and modifications: Phosphorothioate (PTO), 2'-OMe-RNA, 5’-Methyl-dC and other modifications.
  • Flexible synthesis scales: 50 nmol, 100 nmol, 200 nmol, 1 µmol, et al. Bulk orders are available upon request.
  • Experienced team: Scientists and staffs with over 10 years of experience in oligo synthesis and modifications.
  • Cost-saving: Provide high quality antisense oligos with competitive price.
  • Efficiency: We are able to provide the fastest turnaround time of any supplier in the industry.


  1. Rinaldi C. & Wood M.J. (2018). Antisense oligonucleotides: the next frontier for treatment of neurological disorders. Nature Reviews Neurology, 14(1), 9.
  2. Miller C.M. & Harris E.N. (2016). Antisense oligonucleotides: treatment strategies and cellular internalization. RNA & disease (Houston, Tex.), 3(4).
  3. DeVos S.L. & Miller T.M. (2013). Antisense oligonucleotides: treating neurodegeneration at the level of RNA. Neurotherapeutics, 10(3), 486-497.

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