Tissue Specific AAV Particles

A tissue-specific promoter is active in only certain cell types which can restrict unwanted transgene expression. Tissue specific promoters are useful in gene therapy to ensure the safety of a gene-therapeutic drug for normal tissues. Many tissue-specific promoters have been identified and widely used for driving gene expression in specific type of cells or tissues such as neural cells, liver cells, muscle cells, astrocytes etc.

Creative Biogene offers premade AAV particles that contain different tissue-specific promoters including neuron-specific promoters (synapsin, CaMKII), liver-specific promoters (TBG, ApoE/AAT1), muscle-specific promoters (tMCK, MHCK7), cardiac muscle-specific promoters (αMHC, cTNT), astrocyte-specific promoter GFAP.

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