Virus-Related Researches

ENVLPE: A Revolutionary Breakthrough in Gene Editing Delivery Technology

On April 9, 2025, a groundbreaking study published in Cell introduced a novel delivery technology called ENVLPE (Engineered Nucleocytosolic Vehicles for Loading of Programmable Editors), developed by a team of scientists from the Helmholtz Munich Center and the Technical University of Munich.

Adenoviral Vectors as Excellent Tools for Vaccine Development

Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its utility as a vaccine vector has continued to increase.

AAV in The Treatment of Heart Disease

Cardiovascular disease is a major cause of mortality affecting human beings. In recent years, gene therapy has emerged as a promising approach for treating and curing damaged cardiovascular tissues, capable of restoring the heart from a nonfunctional state to a normal state.

Adeno-Associated Viral Vectors (AAV) and Their Applications in Lung Diseases

Adeno-associated virus (AAV) belongs to the family of parvoviridae, the viral particles have no envelope, and the structure is an ortho icosahedron with a diameter of about 20 nm.

AAV: An Introduction to the Tools Used for Gene Expression in Mammals

Adeno-associated virus (AAV) has become a popular viral tool for research and clinical applications.

Overcoming Obstacles in Scaling Up Production of AAV-Based Gene Therapy

Creative Biogene presents to clients how successful applications in antibody production development translate into AAV to meet the challenges of scaling up their production.

Harnessing Self-Amplifying RNA Viruses Revolutionizing RNA Vaccines

Creative Biogene introduces customers to the basic functions of self-replicating RNA viral vectors and describes various pre-clinical and clinical applications.

Potential Applications of Adenovirus-Mediated Gene Delivery in Gene and Cell-Based Therapies

There has been a long-lasting interest in using viral vectors, especially adenoviral vectors, to deliver therapeutic genes for the past two decades. Among all currently available viral vectors, adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.

Innovations in Gene Editing: Use of Cas9 Viral Particles in CRISPR Delivery

To fully exploit the gene editing potential of CRISPR/Cas9, they must be efficiently introduced into target cells or tissues using appropriate vectors. Recombinant viral vectors have been developed using ability of viruses to transfer foreign genetic material into cells to deliver therapeutic genes to diseased tissues.

Clinical Prospects for Integrase-Deficient Lentivirus (IDLV)

HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. Genetic material transduced by lentiviral vector is integrated into the cell genome to introduce new functions, repair defective cell metabolism, and stimulate certain cell functions.

* For research use only. Not intended for any clinical use.

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