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GPCR Stable Cell Lines

GPCR (G protein-coupled receptors), are important proteins in cell signaling, with the ability to bind the nucleotides guanosine triphosphate (GTP) and guanosine diphosphate (GDP). GPCR are the largest and most diverse group of membrane receptors in eukaryotes, and play a role in an incredible array of functions in the human body, from sensation to growth to hormone responses. The findings suggest that the topological conformation of GPCR is a seven-transmembrane domain. When the ligand outside the membrane interacts with GPCR, part of the receptor inside the membrane activate a nearby G protein through binding and interaction, and thus initiate different signal transduction pathways, as well as various biological effects.

GPCR Stable Cell Lines

The key point for new drugs research and development is to find, identify and prepare the drug targets. In more than 500 drug targets which have been discovered, GPCR occupy the majority, approximately 50%. Increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third and one-half of all marketed drugs act by binding to GPCR. GPCR have been widely used to screen drugs and study the etiology and pathogenesis of autoimmune diseases. So it’s necessary for researchers to build GPCR stable over-expressing cell lines.

Creative Biogene has professional research team and advanced technological platform, and can provide a series of GPCR over-expressing cell lines to meet all your needs. So far, Creative Biogene has successfully constructed GPCR over-expressing stable cell lines of various species, which has become one of the world's largest banks of GPCR cells. These cell lines have been verified in the functionality and stability through reporter gene assay or intracellular calcium assay, to satisfy our customers’ requirements for screening GPCR-target drugs and final evaluation.

Applications

  • Study the specific interactions between GPCRs and their ligands, to better reveal the mechanism of cell signaling.
  • Construct cell models for high throughput drugs screening to discover the etiology and pathogenesis of autoimmune diseases and provide a solution.

Advantages

  • One-stop service: Customized cell generation project was managed by experienced scientists throughout the process, from construction design to drug screening.
  • Experienced: Creative Biogene has professional research team with experience of many years in the field of molecular and cell biology.
  • Broad cell types: Creative Biogene has successfully constructed GPCR over-expressing stable cell lines with 293, CHO, HeLa, 1321N1, U2OS, RH7777 etc.
  • Genetic stability: Our GPCR over-expressing cell lines have been rigorously tested and validated for at least 10 passages continous culture without significant change in assay window.
  • High Quality: Our GPCR over-expressing cell lines have no mycoplasma contamination.
  • Cost & Time saving: There are a lot of choices for premade GPCR stable cells enabling for long-term screening, and ready-to-assay/division-arrested GPCR cells suitable for small scale screening assays.

Table 1. Frequently Requested - GPCR Stable Cell Lines
(Gene official symbol listed from A to Z, h: human, r: rat)

hADCYAP1R1hADORA1hADORA2AhADORA2BhADORA3hADRA1AhADRA1BhADRA1D
hADRA2AhADRA2BhADRA2ChADRB1hADRB2hADRB3hADRBK2hAGTR1
hAPLNRhAPLNR hAVPR1ArAvpr1ahAVPR1BhAVPR2hBDKRB1hBDKRB2
hBRS3hC3AR1hC5AR1hCALCRhCALCRLhCASRhCCKARhCCKBR
hCCR1hCCR10hCCR2hCCR3hCCR4hCCR5hCCR6hCCR7
hCCR8hCCR9hCHRM1hCHRM2hCHRM3hCHRM4hCHRM5hCMKLR1
hCNR1hCNR2hCRHR1hCRHR2hCX3CR1hCXCR1hCXCR2hCXCR3
hCXCR4hCXCR5hCXCR6hCYSLTR1hCYSLTR2hDRD1hDRD2hDRD3
hDRD4hDRD5hEDNRAhEDNRBhF2RL1hFFAR2hFFAR3hFPR1
hFPR2hFSHRhGABBR1hGALR1hGALR2hGCGRhGHRHRhGHSR
hGIPRhGLP1RhGLP2RhGNRH1hGNRHRhGPBAR1hGPR119hGPR39
hGPR68hGRM1hGRM2hGRPRhH3F3AhHCAR2hHCRTR1hHCRTR2
hHRH1hHRH2hHRH3hHTR1AhHTR2AhHTR2BhHTR2ChHTR4
hHTR6hHTR7hKISS1RhLPAR1hLPAR2hLPAR3hLPAR5hLTB4R
hMC2RhMC3RhMC4RhMC5RhMCHR1hMCHR2hMLNRhMRGPRD
hMRGPRX1hMRGPRX2hMTNR1AhNMBRhNMUR1hNMUR2hNPBWR1hNPSR1
hNPY2RhNPY4RhNTSR1hO3FAR1hOPRD1hOPRK1hOPRL1hOPRM1
hOXGR1hOXTRhP2RY1hP2RY11hP2RY12hP2RY2hP2RY4hPPYR1
hPRLHRhPROKR1hPROKR2hPTAFRhPTGDRhPTGDR2hPTGER1hPTGER2
hPTGER3hPTGER4hPTGFRhPTGIRhPTH1RhPTH2RhQRFPRhQRFPR
hS1PR1hS1PR2hS1PR3hS1PR4hS1PR5hSCTRhSSR2hSSTR1
hSSTR2hSSTR3hSSTR4hSSTR5hSUCNR1hTACR1hTACR2hTACR3
hTBXA2RhTRHRhTSHRhUTS2RhVIPR1hVIPR2hXCR1 

Table 2. Available For Ready-To-Assay/Division-Arrested GPCR Cells
(Gene official symbol listed from A to Z, h: human, m: mouse, r: rat, d: dog)

hADCYAP1R1hADORA1hADORA2AhADORA2BrAdora2bhADORA3hADRA1AhADRA1B
hADRA1DhADRA2AhADRA2BhADRA2ChADRB1hADRB2hADRB3hADRBK2
hAGTR1hAPLNRhAPLNR hAVPR1AhAVPR1BhAVPR2hBDKRB1hBDKRB2
hBRS3hC3AR1hC5AR1hCALCRhCALCRLhCASRrCasrhCCKAR
hCCKBRhCCR1hCCR10hCCR2hCCR3hCCR4hCCR5hCCR6
mCcr6hCCR7hCCR8hCCR9mCcr9dCcr9rCcr9hCHRM1
hCHRM2hCHRM3hCHRM4hCHRM5hCMKLR1hCNR1hCNR2hCRHR1
hCRHR2hCX3CR1hCXCR1hCXCR2hCXCR3hCXCR4hCXCR5hCXCR6
hCXCR7hCYSLTR1hCYSLTR2hDRD1hDRD2hDRD4hDRD5hEDNRA
rEdnrahEDNRBhF2RhF2RL1hFFAR1rFfar1mFfar1hFFAR2
rFfar2mFfar3hFFAR3rFfar3hFPR1hFPR2hFSHRhGABBR1
hGALR1hGALR2hGCGRhGHRHRmGhsrhGHSRhGIPRhGLP1R
hGLP2RhGNRH1hGNRHRrGpbar1hGPBAR1mGpbar1hGPR119hGPR142
mGpr183hGPR3hGPR35hGPR37L1hGPR39hGPR50hGPR55hGPR68
hGPR84hGRM1hGRM2hGRM3rGrm4hGRM4mGrm4 hGRM5
hGRM6hGRM7hGRM8hGRPRhH3F3AhHCAR2hHCAR3hHCRTR1
hHCRTR2hHRH1hHRH2hHRH3mHrh3hHRH4mHrh4hHTR1A
hHTR1BdHTR2AhHTR2AhHTR2BhHTR2ChHTR4hHTR6hHTR7
rKiss1rhKISS1RhLPAR1hLPAR2hLPAR3hLPAR4hLPAR5mLpar5
hLTB4RhLTB4R2hMC2RhMC4RhMC5RrMchr1hMCHR1hMCHR2
hMLNRhMRGPRDhMRGPRX1hMRGPRX2hMTNR1AhMTNR1BmMtnr1brNmbr
hNMBRhNMUR1hNMUR2hNPBWR1rNpbwr1hNPBWR2mNpsr1hNPSR1
hNPY1RhNPY2RrNpy2rhNPY5RhNTSR1hO3FAR1rO3far1mO3far1
rOprd1hOPRD1rOprk1hOPRK1hOPRL1rOprl1rOprm1hOPRM1
hOXGR1hOXTRhP2RY1hP2RY11rP2ry12hP2RY12hP2RY13hP2RY14
hP2RY2rP2ry2hP2RY4hP2RY6hPPYR1hPRLHRhPROKR1hPROKR2
hPTAFRhPTGDRhPTGDR2hPTGER1hPTGER2hPTGER3hPTGER4hPTGFR
hPTGIRhPTH1RhPTH2RhQRFPR hRXFP1hRXFP3hS1PR1hS1PR2
hS1PR3hS1PR4hS1PR5hSCTRhSMOhSSR2hSSTR1hSSTR2
hSSTR3hSSTR4hSSTR5hSUCNR1rTaar1hTAAR1hTACR1hTACR2
hTACR3hTBXA2RhTRHRrTshrhTSHRhUTS2RrUts2r hVIPR1
hVIPR2hXCR1 

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