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During the development of GMP cell lines, the screening and evaluation of cell lines is important for the subsequent generation of cell lines with desired production properties. In order to identify efficient clones for further process development, scale-up and production, multiple steps in the cell line production process need to be performed to obtain stability of the expression products. Creative Biogene uses our advanced platform process to screen cell lines for further production of the best performing cell lines for maximum productivity and desired product characteristics.
Since individual host cells do not always achieve optimal productivity and bioactivity, screening for suitable expression hosts is critical to obtain the desired product properties according to the production needs of biotherapeutics. In Creative Biogene's lab, we utilize advanced technologies and platforms to screen and evaluate stable, high-yielding host cell lines with good growth viability, which is the starting point for project development for all our clients.
Creating stable and production-ready cell lines is often complex and time-consuming. Creative Biogene is a leading expert in customizing and designing stable cell lines for you using powerful and reliable gene editing technologies. We have extensive experience in editing cells from a variety of backgrounds, including HEK 293, T cells, and NK cells. Our scientists are always customer-focused, designing your cell lines according to your project needs and performing quality control tests to ensure that the generated cell lines meet your requirements.
To obtain a stably expressed cell line, the pool of cells obtained after transfection needs to be screened for positive clones. Creative Biogene quickly and accurately selects the optimal cell pool for subsequent production by cell sorting or antibiotic selection.
To obtain stably transfected monoclonal cell lines, further monoclonal screening is required. Creative Biogene has advanced instrumentation and analytical platforms, such as ClonePix, that allow us to achieve optimal clone selection based on quality and quantity in a short period of time.
Creative Biogene has a state-of-the-art cGMP manufacturing facility where we establish MCB, WCB cell banks under GMP conditions. Through our cell banking platform, we can help our clients to easily transfer cell culture parameters for subsequent pilot or commercial scale product production.
Creative Biogene offers GMP-validated genetic stability testing of cell lines. Our experienced scientists select the most appropriate and cost-effective testing strategy to meet the regulatory requirements for biologics manufacturing.
Cell Line Characterization
Creative Biogene provides integrated solutions for the full characterization of cell lines and cell banks through advanced analytical and characterization platforms. Our characterization services are highly accurate and sensitive, ensuring that the quality of the delivered cell lines is up to standard.
Creative Biogene, a leading provider of GMP cell line development services, has accumulated extensive experience in cell line screening and characterization. Our competitive pricing and professional services have earned the trust of our global collaborators. Please feel free to contact us if you have a need, and our experienced specialists will be happy to assist you.
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