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circRNA Service

Creative Biogene is a global biotechnology company devoting to offer high-quality service for customers. We provide a one stop solution for circRNA prediction, identification, preliminary screening, functional analysis and circRNA-miRNA/RBP interaction mechanism analysis to accelerate your biomarker discovery and drug development research. Supported by our experienced scientists and advanced technology, Creative Biogene will work closely with you to meet your requirements.

circRNA is an emerging class of widespread, abundant and evolutionarily conserved noncoding RNA, and generated by non-sequential back splicing of exons, introns or both. In this century, the vital functions of circRNAs in eukaryotes have increasingly come to light. Recently, with the development of RNA sequencing and microarray, thousands of types of circRNAs have been found to be endogenous in mammalian cells. Various physiological functions are associated with circRNAs, such as acting as miRNA sponges, RNA banding protein sponges, protein translation templates and regulation of gene expression. In addition, circRNAs are abundant in eukaryotes, and are involved in many diseases, including different cancers and autoimmune diseases.

Putative roles of circRNAs in antitumor immune regulation and immunotherapy Fig 1. Putative roles of circRNAs in antitumor immune regulation and immunotherapy

To discover and identify circRNA involved in diseases, Creative Biogene detects genome-wide circRNA expression by circRNA sequencing or circRNA microarray. We generally run multiple circRNA prediction algorithms to minimize the number of false positives and ensure the accuracy of results.

For the stringent circRNA analysis methods, northern blot and RT-qPCR are available to fully characterize the expression level of candidate circRNAs. Fluorescence in situ hybridization (FISH) is used in providing localization information about specific circRNAs. Besides, we also offer circRNA inhibition and overexpression service, which assist clients to modulate the expression of circRNA. This may act as a more powerful evidence to reveal the function of circRNA in cancer cell proliferation and apoptosis.

Creative Biogene utilizes several methods to explore the detailed binding sites for circRNA-miRNA and circRNA-RBP (RNA binding protein) interactions, including RNA immunoprecipitation (RIP) combined with luciferase reporter assay, RIP followed by sequencing, and RNA pull down combined with mass spectrometry. On this basis, Creative Biogene is a reliable partner that can work with you to accelerate the speed to achieve your research goals.

In addition, all of our circRNA services are generally used for research purposes only and not for clinical diagnosis. If you have additional requirements or questions, please feel free to contact us at or 1-631-626-9181.


  1. Xu, Z. (2018). The potential role of circRNA in tumor immunity regulation and immunotherapy. Frontiers in Immunology, 9:9
  2. Zhang, M. (2018). Circular RNAs: a new frontier for cancer diagnosis and therapy. Journal of Hematology & Oncology, 11(1), 21.

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