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Seasonal influenza, also known as the flu, often causes severe illness and mortality in highrisk human populations such as children and the elderly. It is a contagious respiratory illness which is caused by infection of influenza viruses. The symptoms of influenza range from mild to severe, including fever, runny nose, sore throat, muscle pain, headache, coughing and fatigue, and can lead to hospitalization and death.
Influenza viruses have a negative-sense, single-stranded RNA genome that is segmented. They belong to the Orthomyxoviridae family and have been divided into four types, influenza type A, B, C and D. The type A and B influenza viruses are responsible for most cases of severe illness as well as seasonal epidemics and occasional pandemics, while influenza C virus only causes a mild infection and influenza D virus is not known to cause illness.
Pseudoviruses are valuable tools in the field of biomedical research and have been widely used in virology research. Pseudoviruses often use the envelope protein(s) from the target virus but lacks the genetic material required for replication and infection. They allow researchers to study viral entry mechanisms and screen antiviral drugs in a safe manner without the risk of causing disease.
Figure 1. Schematic structure of influenza pseudovirus
The employment of influenza pseudoviruses has been widely reported. Creative Biogene has over 10 years of experience in various types of viruses. In order to support the research of pandemic and seasonal influenza viruses, our scientists have developed a variety of influenza A and B pseudoviruses. These influenza pseudoviruses contain a heterologous virus core, a GFP or luciferase reporter gene, and the influenza proteins (HA and NA). They are infectious for a single cycle but are unable to make infectious progeny, allowing researchers to handle them on lower biosafety containment levels.
1) Pseudotype-based antibody neutralization assays for influenza viruses
2) Influenza serological studies such as the measurement of seroprevalence
3) Screening and validation of antiviral drugs specific for influenza
4) High-throughput assays
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