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Creative Biogene is offering ion channel drug screening services. As a well-known expert in this field, our talented scientists with innovative technology platforms are confident in offering high-efficiency service for your discovery programs with the most competitive price.
Fig.1 The structure of ion channel
Creative Biogene has generated an extensive panel of ion channel screening assays comprising more than 80 ion channel targets and over 200 ion channel assays. In terms of conventional patch clamp electrophysiology, automated electrophysiology, and fluorescence assays, Creative Biogene can offer a wide range of binding and functional assays for ion channel assays to quickly and accurately provide results for drug discovery.
Ion channels are pore-forming membrane proteins that create a gated, water-filled pore to help establish and control voltage potential across cell membranes through control of the active flow of ions between the intracellular and the extracellular environments (Sharan et al. 2013). As key components in a wide variety of biological processes involved in rapid changes in cells (e.g. cardiac/skeletal/smooth muscle contraction, and epithelial transport of nutrients), ion channels are important therapeutic targets in a range of indications, including cardiac, CNS, immune system and metabolic diseases. Due to the development of screening technologies, a dramatically increased interest has been shown in ion channels for hit validation, potency determination, selectivity profiling and lead optimization.
Over ten years’ experience in this field has enabled Creative Biogene to better understand our customers' latent demands. Our scientific experts are ready to reduce the risk and maximize the success of your discovery programs. Through conducting against ion channels from a large collection expressed in mammalian cells, a compound’s ion channel potency, efficacy, specificity or potential for off-target effects can also be high-throughput identified in early drug discovery at Creative Biogene. Moreover, off-the-shelf or custom assays are offered for screening and profiling ion channel targets as well, which including major cardiac, CNS and PNS channels.
Whether you are doing HTS or lead optimization against your target of interest, Creative Biogene can provide a validated assay and platform fit for the purpose. Our flexible service allows any single channel or combination of channels to be tested as part of a customized panel, we can use your specified concentration range and assay protocol as well if desired. As a well-recognized provider in ion channel related services, Creative Biogene is pleased to tailor the best-fit protocol to meet your specific demands and also facilitate your research and project development.