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Gene therapy has become a revolutionary approach to treat genetic diseases, cancer, and other life-threatening diseases. Adeno-associated virus (AAV) is one of the most widely used viral vectors for gene therapy due to its safety, low immunogenicity, and ability to efficiently deliver therapeutic genes. However, one of the major challenges for AAV-based therapies is the presence of pre-existing or induced anti-AAV antibodies in patients, which may neutralize the viral vector, reduce transduction efficiency, and reduce the therapeutic effect.
To address this critical issue, Creative Biogene has developed highly sensitive and specific anti-AAV antibody ELISA kits for the detection and quantification of neutralizing antibodies against AAV serotypes in human and animal serum samples. These kits play a key role in preclinical and clinical studies, allowing researchers to evaluate immune responses before and after AAV vector administration to ensure the safety and efficacy of gene therapy.
Our Anti-AAV Antibody ELISA Kits utilize highly specific monoclonal antibodies that recognize intact AAV capsids (AAV1-AAV9) of specific serotypes. The assay is a sandwich ELISA where:
(1) Serotype fidelity: very low cross-reactivity between different AAV serotypes (<5%).
(2) Sensitivity: can detect neutralizing antibodies (NAbs) at dilutions up to 1:1000.
(3) Wide Serotype Coverage: Supports detection of antibodies against multiple AAV serotypes (AAV2, AAV5, AAV8, AAV9, etc.).
(4) User-Friendly: Ready-to-use reagents with optimized protocols for consistent performance.
(5) Throughput: 96-well plate allows for large-scale screening.
Creative Biogene's anti-AAV antibody ELISA kits provide indispensable tools for researchers in the field of gene therapy. These kits can accurately and reliably detect neutralizing antibodies, which can help optimize treatment strategies, improve gene therapy safety, and enhance the success rate of AAV therapies.
| Cat.No. | Product Name | Price |
|---|---|---|
| AAEK0001 | Human Anti-AAV2 antibody ELISA Kit | Inquiry |
| AAEK0002 | Human Anti-AAV5 antibody ELISA Kit | Inquiry |
| AAEK0003 | Human Anti-AAV6 Antibody ELISA kit | Inquiry |
| AAEK0004 | Human Anti-AAV8 antibody ELISA Kit | Inquiry |
| AAEK0005 | Human Anti-AAV9 antibody ELISA Kit | Inquiry |
| AAEK0006 | Monkey Anti-AAV2 Antibody ELISA Kit | Inquiry |
| AAEK0007 | Monkey Anti-AAV5 Antibody ELISA Kit | Inquiry |
| AAEK0008 | Monkey Anti-AAV6 Antibody ELISA Kit | Inquiry |
| AAEK0009 | Monkey Anti-AAV8 Antibody ELISA Kit | Inquiry |
| AAEK0010 | Monkey Anti-AAV9 Antibody ELISA Kit | Inquiry |
| AAEK0011 | Mouse Anti-AAV2 antibody ELISA Kit | Inquiry |
| AAEK0012 | Mouse Anti-AAV5 antibody ELISA Kit | Inquiry |
| AAEK0013 | Mouse Anti-AAV6 Antibody ELISA kit | Inquiry |
| AAEK0014 | Mouse Anti-AAV8 antibody ELISA Kit | Inquiry |
| AAEK0015 | Mouse Anti-AAV9 antibody ELISA Kit | Inquiry |
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