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Tyrosine kinases play a central role in transmembrane signal transduction, mediating cellular responses to growth factors, cytokines, and environmental cues. Dysregulation of tyrosine kinase signaling is closely associated with cancer, immune disorders, and developmental abnormalities.
Our Tyrosine Kinase recombinant protein portfolio is designed to support receptor-focused research, providing structurally defined extracellular domains and functional constructs suitable for biochemical, biophysical, and cell-based studies.
Unlike soluble ligands or intracellular enzymes, receptor tyrosine kinases (RTKs) function through ligand binding, receptor dimerization, and spatial organization at the cell surface. This portfolio is developed to support experimental systems that interrogate these critical early signaling events.
Ligand–Receptor Interaction Studies
Recombinant extracellular domains of tyrosine kinases are suitable for analyzing ligand binding, affinity determination, and interaction specificity using biochemical and biophysical assays.
Receptor Activation and Dimerization Models
Fc-fusion and defined extracellular constructs support studies of receptor dimerization, clustering, and activation mechanisms that precede intracellular kinase signaling.
Cell-Based Signaling and Functional Assays
Tyrosine kinase proteins are widely used as reagents in cell-based assays to validate receptor engagement, pathway activation, and downstream biological responses.
Oncology and Disease-Associated Research
Many tyrosine kinases represented in this portfolio are well-established tumor-associated antigens or disease-relevant targets, supporting cancer biology, biomarker research, and therapeutic discovery efforts.
This portfolio includes a broad range of receptor tyrosine kinases involved in growth factor signaling, immune regulation, angiogenesis, and developmental pathways.
Target coverage includes, but is not limited to:
Multiple species options are available, including human, mouse, rat, cynomolgus monkey, and rhesus macaque, enabling translational and comparative studies.
To support diverse experimental needs, tyrosine kinase proteins are offered in multiple construct designs focusing on extracellular and functional regions.
Available formats include:
Expression regions are carefully selected to preserve receptor-binding interfaces and native folding characteristics.
Given the structural complexity and glycosylation requirements of receptor tyrosine kinases, the majority of proteins are produced using mammalian expression systems to support proper folding and post-translational modifications.
Where appropriate, alternative expression systems are employed for defined fragments or specialized applications.
Tyrosine kinase signaling studies often rely on subtle binding and activation events. Each recombinant protein is manufactured under standardized quality control processes designed to support sensitive and reproducible assays.
Key quality attributes include:
This Tyrosine Kinase recombinant protein portfolio is supplied for research use only and is designed to support both fundamental receptor biology studies and translational research programs. Broad target coverage, multiple construct formats, and application-driven design enable flexible integration into complex experimental workflows.
For detailed target availability, construct formats, species options, or technical support, please explore individual product pages or contact our technical support team.
| Cat.No. | Product Name | Price |
|---|---|---|
| RP00001 | Recombinant Cynomolgus HER2 (C-Fc) | Inquiry |
| RP00006 | Recombinant Human ROR1 (C-Fc) | Inquiry |
| RP00011 | Recombinant Human HER2 (C-Fc) | Inquiry |
| RP00020 | Recombinant Human HER3 (C-6His) | Inquiry |
| RP00027 | Recombinant Human ROR1 (C-6His) | Inquiry |
| RP00040 | Recombinant Human HER2 (C-6His) | Inquiry |
| RP00041 | Recombinant Human EGFR (C-6His) | Inquiry |
| RP00050 | Recombinant Mouse DDR1 (C-6His) | Inquiry |
| RP00059 | Recombinant Human ROR1 (Frizzled domain, C-6His) | Inquiry |
| RP00065 | Recombinant Mouse DDR1 (C-6His) | Inquiry |
| RP00066 | Recombinant Human ROR1 (Kringle domain, C-6His) | Inquiry |
| RP00074 | Recombinant Human ROR1 (Ig-like domain, C-6His) | Inquiry |
| RP00081 | Recombinant Human ROR1 (Kringle domain, C-6His) | Inquiry |
| RP00083 | Recombinant Rhesus Macaque DDR1 (C-6His) | Inquiry |
| RP00084 | Recombinant Cynomolgus AXL (C-Fc) | Inquiry |
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