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A genome isn’t just an abstract sequence of nucleotides – it is a collection of DNA molecules packaged inside of our cells. Epigenetics connects the genome with its functional output. A variety of epigenetic marks have been described, ranging from DNA (such as DNA methylation) to histone modifications, which is able to affect the way that cell reads its genome and hence its transcriptional output. Transcription factors that bind to DNA can alter or create epigenetic states (such as open or closed chromatin and higher-order chromatin conformation), or their binding can be sensitive to preexisting epigenetic states. Some epigenetic marks can also be heritable from one cell generation to the next or from one organism generation to the next (i.e., intergenerational or transgenerational epigenetic inheritance).
Figure 1. Epigenetics connects the genome with its functional output.
Epigenomic technologies enable us to look beyond the genome sequence, revealing information about how the genome actually exists in individual cells, including bound by proteins, modified by enzymes, and folded inside the dynamic 3-dimensional space of the cell's nucleus. This epigenetic information is important for understanding how each cell type in the human body functions during normal development, and how their function goes amiss in disease.
Creative Biogene, as a leading biotechnology company, is able to offer comprehensive epigenomics profiling services to help researchers explore the function of various aspects of the epigenome in the context of human biology and disease. These aspects include histone modification, transcription factor binding, chromatin accessibility, and 3D chromatin architecture, in both bulk samples and in single-cell resolution.
Creative Biogene can provide epigenome-wide analyses for understanding epigenetic mechanisms, transgenerational epigenetics studies, epigenetics-related drug discovery, functional epigenomics, and epigenetic biomarker identification (including epigenomic cancer biomarkers). If you have any special requirements in epigenetics profiling services, please feel free to contact us at or 1-631-626-9181. We are looking forward to working together with your attractive projects.