miRNA Clones

Brief Introduction

miRNA Clones

MicroRNAs comprise a novel class of endogenous, small (only about 20 to 25 nucleotides), and noncoding RNAs. MicroRNAs, in common, play the similar roles as transcription factors by specifically binding the seed sequence within 3’UTR of target genes, by activating their degradation or inhibiting their translation of the target genes mRNAs or inhibit their translation, which result in variety of cell activities changing at different levels. MicroRNA (miRNA) has emerged as an important regulator of gene expression in plants. 146 miRNAs were identified by bioinformatic analysis and RNA library sequencing.

Creative Biogene has developed an advanced vector-based miRNA expression plasmids, which can help to ease the difficulty in your research. These purified and ready to transfect miRNA expression plasmids can be used for a variety of applications to down-regulate gene expression. Besides, we can also provide miRNA mimics and inhibitors which enhance or block miRNA regulation of target gene expression. Especially miRNA inhibitors, they are designed and optimized for miRNA loss of function study.

Publications

Forget B, Garcia E M, Godino A, et al. Cell-type-and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons[J]. Molecular psychiatry, 2022, 27(2): 918-928.
Zhou Q Y, Yang H M, Liu J X, et al. MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7[J]. Parasites & Vectors, 2021, 14(1): 1-12.
Xiao-Mei C, Jin-Yu Z, Yan-Lang Y, et al. Pristimerin improve renal fibrosis by regulating miRNA-145-5p in vitro and vivo study[J]. Food Science and Technology, 2021, 42: e79021.
Redweik G A J, Horak M K, Hoven R, et al. Evaluation of live bacterial prophylactics to decrease IncF plasmid transfer and association with intestinal small RNAs[J]. Frontiers in Microbiology, 2021: 3581.
Wang Z, Liu C. MiR-153 regulates metastases of gastric cancer through Snail[J]. Tumor Biology, 2016, 37: 15509-15515.
Gao F, Wang T, Zhang Z, et al. Retracted Article: Regulation of activating protein-4-associated metastases of non-small cell lung cancer cells by miR-144[J]. Tumor Biology, 2016, 37: 15535-15541.
Shi Y, Tan Y, Zeng D, et al. RETRACTED ARTICLE: miR-203 suppression in gastric carcinoma promotes Slug-mediated cancer metastasis[J]. Tumor Biology, 2016, 37(12): 15483-15488.
Wang B, Zhong Y, Huang D, et al. Macrophage autophagy regulated by miR-384-5p-mediated control of Beclin-1 plays a role in the development of atherosclerosis[J]. American Journal of Translational Research, 2016, 8(2): 606.
Peng Z, Xu T, Liao X, et al. RETRACTED ARTICLE: Effects of radiotherapy on nasopharyngeal carcinoma cell invasiveness[J]. Tumor Biology, 2016, 37(12): 15559-15566.
Zhang Y J, Liu X C, Du J, et al. MiR-152 regulates metastases of non-small cell lung cancer cells by targeting neuropilin-1[J]. International journal of clinical and experimental pathology, 2015, 8(11): 14235.
Yu Z, Zhang Y, Gao N, et al. Overexpression of miR-506 inhibits growth of osteosarcoma through Snail2[J]. American journal of translational research, 2015, 7(12): 2716.

* For research use only. Not intended for any clinical use.

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