Creative Biogene provides a top-ranking Apoptosis Biochemical Screening and Profiling Services. Our team of expert together with our broad services portfolio makes us confident in offering with high quality data with fast turnaround time.
Apoptosis, a form of programmed cell death, is a natural process for removal of diseased, damaged or unwanted cells such as those with potentially harmful mutations, aberrant substratum, or alterations in cell-cycle control. It plays a central role in proper embryonic development, immune system function, and hormone-dependent atrophy. The activation or inhibition of apoptosis has therapeutic value in cancer or HIV and neurodegenerative diseases.
Apoptosis can be triggered by two known pathways: the intrinsic pathway (also called the mitochondrial pathway) and the extrinsic pathway. The intrinsic pathway, as its name implies, is activated by intracellular stimuli such as irreparable genetic damage, hypoxia, extremely high concentrations cytosolic Ca2+ and severe oxidative stress. This pathway is closely regulated by a group of proteins belonging to the Bcl-2 family and is the result of increased mitochondrial permeability and the release of pro-apoptotic molecules such as cytochrome c into the cytoplasm. The other pathway, extrinsic pathway is initiated when extracellular ligands binding to cell-surface death receptors. The best known death receptors are the type 1 TNF receptor (TNFR1) and a related protein called Fas (CD95) and their ligands are called TNF and Fas ligand (FasL) respectively.
Fig.1 Two pathways of apoptosis
An understanding of the mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. In some cases, the problem is due to too much apoptosis, such as in the case of degenerative diseases while in others, too little apoptosis is the culprit. Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies. With years of development, Creative Biogene has the expertise and ability in offering a broad and comprehensive service in apoptosis biochemical screening and profiling.
Creative Biogene is able to provide the following apoptosis biochemical screening and profiling services for your scientific research:
Screening and profiling of a broad range of apoptosis inhibitors / targets
Select from IC50 determination and single point concentrations
Information on an essential family of apoptosis targets responsible for a wide range of on- and off-target biological processes
Biochemical assays of BCL-2 family proteins and Caspase
With years of experience and expertise in this field, Creative Biogene can provide you the best services and highest quality results for your apoptosis biochemical screening and profiling service. Creative Biogene is confident in speeding your project progress and achieving ideal research goals with the most competitive price.
If you have any special requirements in apoptosis biochemical screening and profiling service, please feel free to contact us at firstname.lastname@example.org or 1-631-626-9181. We are looking forward to working together with your attractive projects.
Wong R S Y. Apoptosis in cancer: from pathogenesis to treatment. Journal of Experimental & Clinical Cancer Research, 2011, 30(1): 87.
Fesik S W. Promoting apoptosis as a strategy for cancer drug discovery. Nature reviews. Cancer, 2005, 5(11): 876.