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| General Information | |
| Organism | Homo sapiens, human |
| Cell Line Description | CNE-2Z (also known as CNE-2) is a poorly differentiated human nasopharyngeal carcinoma (NPC) cell line. This cell line was derived from a patient in Southern China—a region known as a high-incidence area for this malignancy. CNE-2Z cells exhibit an epithelial morphology and are characterized by rapid proliferation and exceptionally high metastatic potential. Unlike the well-differentiated CNE-1 cell line, CNE-2Z represents a more aggressive stage of the disease's progression. CNE-2Z is regarded as a foundational model in fields such as Epstein-Barr virus (EBV)-related oncology research, the assessment of radiosensitivity, and the investigation of the molecular mechanisms underlying nasopharyngeal tumor invasion and chemoresistance. |
| Tissue | Nasopharynx |
| Disease | Nasopharyngeal Carcinoma (Poorly differentiated) |
| Morphology | Epithelial-like |
| Gender | Not specified |
| Age | Not specified |
| Product Format | Frozen |
| Growth Mode | Adherent |
| Biosafety Level | 1 (Biosafety classification is based on U.S. Public Health Service Guidelines) |
| Applications | 1. Nasopharyngeal carcinoma (NPC) pathogenesis and metastasis research 2. Study of EBV-host cell interactions and viral oncogenesis 3. Evaluation of radiosensitivity and radiation-induced DNA damage 4. Screening for novel chemotherapeutic and anti-angiogenic agents 5. Investigation of hypoxia-inducible factors in NPC progression |
| Shipped In | Dry ice |
| Storage Temperature | −196°C |
| Characteristics | |
| Tumorigenic | Yes, in immunocompromised (nude) mice |
| Karyotype | Aneuploid; hypertriploid range |
| Genetic Profile | TP53 mutation; often used in studies involving LMP1 (EBV protein) expression |
| Phenotype | High migration and invasion capabilities in vitro |
| Mycoplasma Test | Negative |
| Culture Conditions and Handling | |
| Subculturing | 1. Remove and discard the culture medium. 2. Briefly rinse the cell layer with PBS (without Ca2+/Mg2+) to remove all traces of serum. 3. Add 2.0 to 3.0 mL of 0.25% Trypsin - 0.53 mM EDTA solution and observe under an inverted microscope until the cell layer is dispersed (usually 3 to 7 minutes). 4. Add 6.0 to 8.0 mL of complete growth medium and gently pipette to obtain a single-cell suspension. 5. Aliquot cell suspension into new culture vessels. |
| Medium Renewal | 2 to 3 times per week |
| Subcultivation Ratio | A split ratio of 1:4 to 1:10 is recommended |
| Culture Conditions | Atmosphere: Air, 95%; CO2, 5%; Temperature: 37°C |
| Cryopreservation | Complete growth medium supplemented with 5% to 10% (v/v) DMSO |
The above is only part of a part of cell line products. If you don't find the cell line you want, Creative Biogene can also provide stable cell line generation service with the best prices and fastest turnaround time for you! Contact us for more information or to request a quote.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RR00750 | Luciferase Reporter Cell Line - CNE-2Z | Inquiry |
| CSC-RR00751 | GFP Reporter Cell Line - CNE-2Z | Inquiry |
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