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cDNA clones play a crucial role in overexpressing specific genes for comprehensive analysis of gene functions, protein structures, biological activities, and dynamics. Creative Biogene offers a diverse range of expression-ready, sequence-verified full-length cDNA clones with both 5'UTR and 3'UTR regions. Our extensive collection includes clones from various species such as human, mouse, and rat, ensuring researchers can easily locate their genes of interest. By providing high-quality cDNA clones, Creative Biogene accelerates research endeavors, empowering scientists to explore and elucidate biological mechanisms effectively. Explore our cDNA clones collection today to advance your research goals.
Key Features of Our Full Length cDNA Clones
Creative Biogene offers expressible, sequence-verified human full-length cDNA clones with 5'UTR and 3'UTR. All sequences were 3' and 5' end sequenced and directionally cloned into mammalian expression vectors.
Creative Biogene offers expressible, sequence-verified mouse full-length cDNA clones with 5'UTR and 3'UTR. Each mouse full-length cDNA clone is fully sequenced and is assured to represent the specified reference sequence.
Creative Biogene can speed up your research by providing high-quality rat full-length cDNA clones, please browse our cDNA clones collection to find your desired one.
Full Length cDNA Clones are meticulously crafted genetic constructs representing specific genes, essential for comprehensive molecular studies. With an extensive array encompassing various species such as mouse, rat, and human, these clones serve as invaluable resources for diverse research applications. These Full Length cDNA Clones from Creative Biogene offer researchers a reliable platform for advancing their molecular biology and biomedical research endeavors:
Case Study 1
Caspase-8 has unique roles in inducing and suppressing apoptosis and necroptosis mediated by death receptors. Researchers aimed to investigate the role of Caspase-8 in regulating RA-induced cell differentiation and necroptosis by utilizing cDNA Clone knockdown. They demonstrated that Caspase-8 knockdown in embryoid bodies derived from ES cells enhanced both RA-induced cell differentiation and necroptosis, dependent on Ripk1 and Ripk3. Notably, the enhancement of RA-induced cell differentiation was independent of Mlkl and necrosome formation. By inducing the expression of RA-specific target genes and RIPK1, RIPK3, and MLKL, RA treatment activated necroptosis. Furthermore, Caspase-8 knockdown led to the translocation of RIPK1 and RIPK3 into the nucleus, forming a complex with RA receptor (RAR) and enhancing RAR binding to RARE. In Caspase-8-deficient embryos, as well as embryos deficient in both Caspase-8 and Mlkl, the expression of RA-specific target genes was significantly enhanced.
Figure 1. Researchers utilized cDNA Clone transfection to investigate the interaction between RIPK1, RIPK3, and RARα and analyze their subcellular localization and protein-protein interactions. (Someda M, et al., 2020)
Case Study 2
Proper flagellar shape and movement in sperm are crucial for successful fertilization. Although the protein outer dense fiber 4 (ODF4) is present in outer dense fibers (ODFs) of the flagellum, its exact role remains unknown. Researchers utilized Odf4 cDNA Clone to investigate the relationship between flagellar shape and movement with ODF4, AK1, and AK2 in spermatozoa. They observed that Odf4−/− sperm flagella exhibited abnormal shape and reduced levels of ODF4, AK1, and AK2, leading to impaired motility and infertility. The study was supported by a rescue experiment, demonstrating that Odf4 restoration reversed the abnormalities and male infertility caused by Odf4 deletion.
Figure 2. RT-PCR and genomic PCR were conducted to analyze ODF4 expression patterns in various tissues and developmental stages. Additionally, transgenic (Tg) mice expressing Odf4-Egfp and Odf2-mCherry were generated to compare the localization of ODF4 and ODF2 in spermatozoa, revealing distinct localization patterns. (Ito C, et al., 2023)
Q: What is the quality of Full Length cDNA Clones?
A: Our Full Length cDNA Clones undergo rigorous sequence verification and quality control to ensure accuracy and reliability. They are constructed using advanced techniques and stringent processes to guarantee high quality.
Q: What research applications are these Full Length cDNA Clones suitable for?
A: Our clones are optimized for immediate use in experiments, saving time and effort and accelerating research progress. They offer a variety of options for different species to meet diverse research needs.
Q: What are the key advantages of Creative Biogene's brand?
A: We are renowned for our outstanding quality control, extensive product selection, and superior customer service, providing researchers with reliable tools to achieve success in biomedical research.
Q: How about the supply cycle and customization services for Full Length cDNA Clones?
A: We have a rapid and efficient supply process with ample stock to meet customer demands promptly. Additionally, we offer customization services to tailor clones according to specific research requirements, providing bespoke solutions for research projects.
| Cat.No. | Product Name | Price |
|---|---|---|
| CDCZ081304 | Mouse Prkar1b cDNA clone (NM_001253890.1) | Inquiry |
| CDCZ081306 | Mouse Prkar1b cDNA Clone (NM_008923.3) | Inquiry |
| CDFG000002 | Human PHF20L1 cDNA Clone(NM_016018.4) | Inquiry |
| CDFG000007 | Human UBE2J1 cDNA Clone(NM_016021.2) | Inquiry |
| CDFG000008 | Human UBE2J1 cDNA Clone(NM_016021.2) | Inquiry |
| CDFG000013 | Human OTUD6B cDNA Clone(NM_016023.3) | Inquiry |
| CDFG000015 | Human OTUD6B cDNA Clone(NM_016023.3) | Inquiry |
| CDFG000018 | Human METTL9 cDNA Clone(NM_016025.3) | Inquiry |
| CDFG000022 | Human SUV420H1 cDNA Clone(NM_016028.4) | Inquiry |
| CDFG000025 | Human TRAPPC12 cDNA Clone(NM_016030.5) | Inquiry |
| CDFG000027 | Human FAM82B cDNA Clone(NM_016033.2) | Inquiry |
| CDFG000031 | Human SBDS cDNA Clone(NM_016038.2) | Inquiry |
| CDFG000035 | Human SBDS cDNA Clone(NM_016038.2) | Inquiry |
| CDFG000042 | Human EXOSC1 cDNA Clone(NM_016046.3) | Inquiry |
| CDFG000044 | Human SF3B14 cDNA Clone(NM_016047.3) | Inquiry |
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