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The most common application of Pseudovirus (PV) is serving as a safer, easier-to-handle alternative to viable viruses, requiring laboratories at only BSL-2. Artificially synthesized PVs contain surface proteins mediating viral entry into host cells, allowing them to infect susceptible cells while halting after only one round. This feature of PVs holds great potential for investigation in viral entry and initial host cell response at lower risk. Previous comparative data has demonstrated the promising similarity between the outcomes from PV- and virus-based assays. Therefore, researchers have now been implementing PV-based model systems to their preliminary research in order to more safely mimic viral infection. Application of such system might also help controlling cytotoxicity caused by infection using full virus since PV replication has only one round. Typically, PVs are engineered to carry reporter genes such as fluorescent proteins or luciferase, allowing for better, more convenient outcome visualization.
-What does Creative Biogene offer?
At Creative Biogene, we have been fully committed to providing our clients with the widest spectrum of therapeutic developmental services aiming at covering every aspects of your quest for novel medication. Examples of services we offer are shown below:
1. Drug/Vaccine Development, Evaluation, and Validation;
3. Therapeutic Compound Delivery Vehicle for Tumor Immunotherapy.
Fig. 1. Mechanism of neutralizing antibody assays (Pavlov et al., 2016).
You are also welcome to submit your own research plans and interests so that our highly experienced team of scientists who are always on standby could provide you with solutions specifically catered to your interests.
-Why Creative Biogene?
Creative Biogene is one of the pioneers offering PV-related services with tested and proven protocols. As the industry leader, Creative Biogene has rich history of success and commitment to providing our clients with the best service using only state-of-the-art equipment and finest materials. Coming from world renowned institutions around the globe, researchers of our laboratory team are well-trained and highly experienced with the devotion and dedication to fulfill any requirements by our clients to satisfactory. At Creative Biogene, industry-leading PV customization service is offered to all of our clients at competitive pricing with rapid turnaround time, ensuring an easy and trouble-free start of your research.
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