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Cytokine receptors are central regulators of immune communication, controlling cell activation, differentiation, survival, and inflammatory responses. Unlike soluble cytokines, cytokine receptors function through multisubunit assembly, ligand-induced conformational changes, and downstream signal transduction, making structurally accurate receptor proteins essential research tools.
Our Cytokine Receptor recombinant protein portfolio is designed to support receptor-centric studies, providing well-defined extracellular domains and engineered formats suitable for biochemical, biophysical, and cell-based applications.
Cytokine signaling is initiated at the cell surface through precise receptor–ligand interactions and receptor complex formation. This portfolio focuses on providing extracellular receptor constructs that preserve native binding interfaces while enabling experimental flexibility.
Ligand–Receptor Binding and Affinity Analysis
Recombinant cytokine receptor extracellular domains support direct analysis of cytokine binding, receptor specificity, and affinity using ELISA, BLI, SPR, and related platforms.
Receptor Complex Assembly and Signal Initiation
Many cytokine receptors function as heteromeric or multimeric complexes. Defined receptor constructs enable studies of receptor pairing, cooperative binding, and ligand-induced receptor assembly.
Immune Regulation and Inflammatory Pathway Research
Cytokine receptors such as IL-2RA, IL-1R1, TNFR family members, and TGF-β superfamily receptors play pivotal roles in immune activation, tolerance, and inflammation, supporting research across immunology, oncology, and autoimmune diseases.
Therapeutic Target Evaluation
Cytokine receptors are key targets for biologics, including antagonistic antibodies, receptor traps, and engineered cytokines. Recombinant receptors enable target validation and functional assessment in therapeutic discovery workflows.
This portfolio includes representative members across major cytokine receptor families, supporting diverse immune signaling pathways.
Coverage includes:
Multiple species options, including human, mouse, cynomolgus monkey, and rhesus macaque, support translational studies and preclinical model development.
To address the structural and functional diversity of cytokine receptors, proteins are engineered with clearly defined extracellular regions while maintaining biological relevance.
Available formats include:
Domain boundaries are selected based on known receptor architecture, such as immunoglobulin-like domains, cysteine-rich regions, or Sushi (CCP) domains, ensuring functional integrity.
Given the structural complexity and glycosylation requirements of cytokine receptors, recombinant proteins are primarily produced using mammalian expression systems. This approach supports correct folding, disulfide bond formation, and post-translational modifications essential for ligand recognition and receptor function.
Cytokine receptor studies often depend on subtle binding and signaling differences. Each protein is manufactured under standardized quality control processes to support reproducibility and experimental confidence.
Key quality features include:
This Cytokine Receptor recombinant protein portfolio is supplied for research use only and is designed to integrate seamlessly into immunology and translational research workflows. Broad receptor coverage, multiple engineered formats, and application-oriented design provide reliable support from fundamental signaling studies to therapeutic development.
For detailed target availability, species options, construct formats, or technical support, please explore individual product pages or contact our technical support team.
| Cat.No. | Product Name | Price |
|---|---|---|
| RP00021 | Recombinant Human CD40 (C-6His) | Inquiry |
| RP00140 | Recombinant Cynomolgus CD40 (C-6His) | Inquiry |
| RP00160 | Recombinant Mouse CD40 (C-Fc) | Inquiry |
| RP00193 | Recombinant Mouse CD40 (C-6His) | Inquiry |
| RP00202 | Recombinant Cynomolgus CD40 (C-Fc) | Inquiry |
| RP00204 | Recombinant Rat CD86 (C-6His) | Inquiry |
| RP00215 | Recombinant Human ACVR2A (C-6His) | Inquiry |
| RP00216 | Recombinant Human ACVR2B (C-6His) | Inquiry |
| RP00244 | Recombinant Human CD40 (C-Fc) | Inquiry |
| RP00274 | Recombinant Human ACVR2B (C-Fc-6His) | Inquiry |
| RP00278 | Recombinant Human CD40 (C-mFc) | Inquiry |
| RP00311 | Recombinant Human ACVR2A (C-Fc-6His) | Inquiry |
| RP00324 | Recombinant Mouse IL-4RA (C-Fc) | Inquiry |
| RP00328 | Recombinant Cynomolgus IL-4RA (C-6His) | Inquiry |
| RP00337 | Recombinant Human IL-2RA (C-6His) | Inquiry |
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