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Chemical modification is the key to improving pairing affinity, metabolic stability, and cellular uptake of RNA and absolutely essential in the discovery and development of highly active RNA therapeutic candidates. Therefore, many of the chemical modifications have been developed to introducing into RNA oligo to improve their thermal stability, serum stability, cellular activity, or pharmacokinetic properties. For instance, the replacement of phosphodiester with phosphorothioate (PS) linkages will reduce cleavage by nucleases and increase the half-life of oligonucleotides in vivo. Besides, chemical modification of the 2’ position of the ribose ring, including 2’-O-methyl (2’-O-meRNA) and 2’-deoxy-2’-fluorouridine can increase stability to degradation by nucleases or improve thermal stability as measured by Tm values. And the elimination of the 2’-hydroxyl may also simplify synthesis, deprotection, and purification protocols and may assist development of methods for obtaining the large amounts of RNA oligo needed for therapeutic applications.
Creative Biogene, as a leading biotechnology company in the world, can offer the dedicated service for the production of modified RNA oligos. Creative Biogene's sophisticated equipments, advanced technologies and highly experienced staffs are available to help you carry out your specific project as cost effectively and quickly as possible, without compromising on quality. If you have any special requirements in our modified RNA oligo synthesis service, please feel free to contact us at . We are looking forward to working together with your attractive projects.
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Creative Biogene is a US-based manufacturer and provider of genomics and proteomics products and services for academic and governmental research institutes, pharmaceutical and biotechnology industry.