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Tumor-Associated Antigens

Tumor-associated antigens (TAAs) are selectively or aberrantly expressed on cancer cells and represent critical targets for oncology research and therapeutic development. Recombinant TAA proteins provide essential tools for target validation, antibody discovery, and functional characterization across diverse cancer indications.

Our Tumor-Associated Antigen recombinant protein solutions are designed to support oncology-focused research programs, with structurally defined extracellular constructs, multiple species options, and application-oriented formats tailored for antibody and cell therapy development.

Built for Oncology Target Discovery and Validation

Unlike broadly expressed receptors or signaling molecules, tumor-associated antigens require high specificity, structural accuracy, and assay compatibility. This portfolio is developed to support the earliest stages of oncology research through to advanced therapeutic evaluation.

Broad Coverage of Clinically Relevant Tumor Antigens

This portfolio covers a wide spectrum of well-established and emerging tumor-associated antigens across solid tumors and hematologic malignancies.

Representative targets include:

  • Glycoproteins and mucins (GPC3, MUC-1, CA125/MUC16, Mesothelin)
  • Cell surface receptors and adhesion molecules (FOLR1, Nectin-4, CEACAM1, GPA33)
  • Developmental and lineage-associated antigens (DLL3, CLDN18.2, CLDN18.1)
  • Immune-modulatory and lectin family targets (Siglec-15, CLEC12A)
  • GPCR- and receptor-associated tumor antigens (GUCY2C, PRLR)

Multiple species options, including human, mouse, cynomolgus monkey, and rhesus macaque, support translational and preclinical model development.

Structurally Defined Extracellular Antigen Constructs

Tumor antigen recognition is highly dependent on epitope presentation and protein conformation. Recombinant proteins are designed to preserve relevant extracellular regions while supporting experimental flexibility.

Available formats include:

  • Full-length or truncated extracellular domains
  • Fc-fusion constructs to enhance stability and avidity
  • His-tagged proteins for biochemical assays and screening workflows
  • Biotinylated proteins for immobilization, BLI/SPR, and high-throughput screening
  • Tag-free or specialized tag constructs for customized applications

Domain-specific constructs are available for select antigens to support epitope-focused studies.

Expression Systems Optimized for Oncology Applications

To ensure native-like folding and post-translational modifications, the majority of tumor-associated antigens are produced using mammalian expression systems. Selected intracellular or truncated antigens are expressed in bacterial systems where appropriate.

Expression strategies are chosen based on antigen complexity, glycosylation requirements, and downstream application needs.

Quality Attributes Supporting Therapeutic Development

Oncology research demands consistent and reproducible reagents. Each recombinant tumor antigen is produced under standardized quality control processes designed to support sensitive binding and functional assays.

Key quality considerations include:

  • High purity and defined molecular composition
  • Structural consistency and reproducibility across batches
  • Compatibility with antibody discovery and cell-based assays
  • Construct transparency to support regulatory-facing research documentation

Available Recombinant Proteins

Integrated Support for Oncology Research Programs

This Tumor-Associated Antigen recombinant protein portfolio is supplied for research use only and is designed to integrate seamlessly into oncology discovery and translational research pipelines. Broad antigen coverage, flexible construct formats, and application-driven design enable reliable support from early target discovery through advanced therapeutic development.

For target availability, construct options, species coverage, or custom project support, please explore individual product pages or contact our technical support team.

* For research use only. Not intended for any clinical use.
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