Since the 21st century, target-based drug discovery has increasingly replaced traditional structure-based approaches, becoming the dominant strategy in modern drug development. The success of targeted drug development hinges on high-quality, stable recombinant target proteins. As cornerstones of biopharmaceutical R&D, these proteins' quality directly impacts screening accuracy and evaluation reliability.
Creative Biogene delivers an extensive portfolio of recombinant drug target proteins with exceptional batch-to-batch consistency, leveraging advanced expression systems and optimized post-translational modifications. Our comprehensive protein collection, manufactured under global pharmacopeia standards and supported by a traceable supply chain, ensures reliable delivery of premium-grade products that meet diverse requirements across the drug development pipeline, from research to GMP-grade levels.
Creative Biogene offers over 500 recombinant target proteins covering membrane receptors, enzymes, immune system-related proteins, and nuclear & transcription regulators. Equipped with purification tags such as His and Fc, each protein is rigorously validated to ensure top-tier activity, purity, and low endotoxin levels, providing reliable support for drug discovery and development. Our advanced expression systems guarantee superior protein quality and consistency.
Immune system proteins are crucial for tumor surveillance and elimination, serving as vital targets for cancer immunotherapy and the development of new therapeutic strategies.
Core to cell signaling, membrane receptors bind signaling molecules, like hormones and neurotransmitters, to initiate biochemical reactions.
Kinases regulate cell signaling and disease progression. Metabolic enzymes impact diseases like diabetes and cardiovascular conditions, while protein-modifying enzymes play a role in cancer and autoimmune treatments.
These proteins regulate gene expression, playing key roles in differentiation, proliferation, and stress responses.
This category encompasses diverse proteins essential for cellular structure, transport, and extracellular interactions, offering further opportunities for therapeutic development.
Target Screening & Validation
Enzyme Activity Assays
Interaction & Structural Analysis
Cell-Based Assays & Biomarker Validation
Engineered E. coli strains optimize protein folding and rare codon usage for efficient expression. Controlled induction ensures precise timing, while chaperone co-expression reduces inclusion bodies, resulting in high-quality protein yields.
Serum-free systems enable consistent output, while site-specific integration, powered by CRISPR technology, guarantees stable expression for reliable biopharmaceutical production.
CFPS enables rapid protein prototype generation in hours, scalable production from µg to mg quantities, and direct incorporation of non-natural amino acids. Molecular chaperone supplementation enhances protein folding for flexible, efficient drug discovery.
Protein identity verification
Secondary structure analysis
Thermal stability assessment
Aggregate analysis
Host cell protein quantification
Endotoxin levels certified
Advanced affinity chromatography with custom-designed ligands ensures maximum protein recovery. Optimized binding and elution conditions enhance purity, while innovative flow-through technology further refines the product. Real-time monitoring of protein quality attributes ensures exceptional product quality.
Multi-modal chromatography removes complex impurities. Ion exchange optimization based on protein characteristics, hydrophobic interaction chromatography for aggregate removal, and advanced membrane separation technology refine the product further.
Ultra/diafiltration with controlled shear rates ensures consistent product quality. Innovative stabilization technology extends shelf life. Custom buffer optimization maximizes stability, while advanced analytical methods verify purity.
>95%
Purity
Our recombinant proteins typically achieve a purity level greater than 95%, as determined by SDS-PAGE and SE-HPLC analysis.
<1.0 EU/µg
Endotoxin
Endotoxin levels are strictly controlled below 1.0 EU/µg protein, ensuring product safety and minimizing potential complications in downstream applications.
<10 pg/mg
Host Cell DNA
Host cell DNA content is carefully monitored and maintained below 10 pg/mg protein, minimizing potential immunogenic reactions and ensuring product purity.
Scientific Excellence
Our continuous R&D investment and academic partnerships drive innovations in recombinant protein development, supported by rigorous validation protocols.
Quality Assurance
ISO 9001:2015-certified facilities and GMP-compliant processes ensure consistent product quality and regulatory compliance.
Technical Support
Our scientists provide comprehensive consultation for protein selection, optimization, and application development, backed by detailed documentation.
Global Accessibility
Temperature-controlled shipping and regional support teams ensure reliable product delivery worldwide, with flexible payment solutions.
Contact our expert team to learn how our products and technologies can contribute to the success of your biopharmaceutical projects. Get in touch today to discover how our technical support can accelerate your drug development process.
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