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The sponge mRNA contains multiple target sites complementary to a miRNA of interest. Stably expressed miRNA sponge is particularly valuable for long-term loss-of-function studies both in vitro and in vivo.
Creative Biogene provides world-class MicroRNA (miRNA) sponge service and we have been perfecting MicroRNA sponge service for many years. Our microRNA sponge is a RNA molecule with 5-8 tandem miRNA binding sequences that can sequester miRNAs from their endogenous target mRNAs.
Compared with antisense oligonucleotide inhibitor and genetic knockout, MicroRNA sponge possesses the following superiority:
|Comparison Item||miRNA Sponge||miRNA Antagomir|
|Composition||mRNA containing a 3' UTR||RNA oligos with chemical modifications|
|Reporter||GFP, luciferase or other reporter proteins||None|
|Specificity||miRNA seed family||Single miRNA|
Creative Biogene provides custom miRNA sponge services to meet your specific needs.
Custom miRNA sponge expression vectors with different combinations of the elements in the following table can be ordered from us. If those elements cannot fulfil your requirement, please contact us for a solution. Our experienced team can always come up with professional services tailored to your needs. Besides, Creative Biogene can also help its clients to construct the lentivirus expression vector and then to package and manufacture high-titer sponge lentivirus particles.