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Phosphorylation is considered to be one of the most common and reversible covalent posttranslational modifications that may alter the activity, life span or cellular location of proteins. Protein kinases can modulate key regulatory proteins involved in different cellular processes, including metabolism, transcription, cell-cycle progression, cytoskeletal rearrangement and cell movement, proliferation, apoptosis and differentiation. Protein phosphorylation also plays a critical role in intercellular communication during development, in physiological responses, in homeostasis and in the functioning of the nervous and immune systems.
It has been shown that abnormal phosphorylation of proteins can lead to the development of a number of disorders and major diseases, such as rheumatoid arthritis, cardiovascular diseases, immunodeficiency, endocrine disorders, neurodegenerative diseases and cancer. Approximately 50 of the 100 known genes that have been directly linked to the induction of cancer (i.e., oncogenes) encode protein kinases. The remainders of the oncogenes specify proteins that either activate kinases or are phosphorylated by kinases. Therefore, it is not a surprise that protein kinases and phosphatases are becoming targets for drug development.
Based on the fundamental role of kinases in cancer progression, drugs against kinases represent a new and promising approach to cancer therapy, one that is already leading to beneficial clinical effects. As a global leader in drug discovery industry, Creative Biogene can offer a variety of Kinase related products including stable cell lines, viral particles and clones for your drug discovery projects in cancer.
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