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Creative Biogene is dedicated to optimize the plant suspension cell-based protein expression platform for years, to product recombinant proteins, polypeptides and industrial proteins for global customers. With years of experience in plant tissue culture and protein expression, Creative Biogene provides a comprehensive service ranging from codon optimization, molecular construction, plant cell transformation to protein expression and purification. Our mission is to help you manufacture complex proteins, antibodies, and vaccines using unique plant expression platform.
Plant suspension culture is emerging as a promising alternative bioproduction platform for recombination proteins, which integrates the merits of whole plant production, microbial fermentation and mammalian cell culture. It offers a number of advantages over traditional expression system such as their intrinsic safety, cost-effective bioprocessing, and the capability for post-translation modifications. With the expression of the first complex recombinant protein (human serum albumin) in tobacco cell culture, a diverse array of pharmaceutical proteins including antibodies, vaccines, hormones, growth factors, cytokines and therapeutic enzymes have been produced in plants.
Tobacco BY-2 (Bright yellow-2) and NT-1 (Nicotiana tabacum-1) are the most frequently chosen plant cell lines used for recombinant protein expression, due to the robust and fast growth. Other commonly used cell lines include rice, alfalfa, tomato, soybean, and carrot.
In comparison to whole-plant cultivation, plant cell culture systems have several notable advantages including: 1) Rapid growth with cell doubling time as short as one day. 2) Controllable plant bioreactor. 3) Fewer regulatory and environmental compliance hurdles for ensuring product quality and safety. 4) Simple procedure for secreted protein isolation/purification from inexpensive.
Workflow of plant cell-based recombinant protein production
Figure 1. Schematic depicting the plant cell suspension culture process for producing recombination proteins
Creative Biogene has developed various cell suspension culture systems for expressing recombination proteins and antibodies. The high levels of expression, along with our efficient purification methods, result in high yield and purity of the final product. In addition, our strict quality management system ensures that the product and its custom purification process can be readily adapted to provide GMP-grade protein for initial and follow-on clinical development. For more information, please feel free to contact us.
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