Kinase Screening & Profiling Services

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Overview

Protein kinases represent one of the most intensively studied and therapeutically validated target classes in modern drug discovery. With more than 500 kinases in the human kinome and deep involvement in cell proliferation, metabolism, survival, and immune regulation, kinase signaling continues to drive innovation across oncology, inflammation, metabolic disease, and beyond.

However, the same structural conservation that makes kinases druggable also makes them difficult. High homology across ATP-binding sites, pathway redundancy, and context-dependent signaling frequently lead to selectivity liabilities and late-stage attrition—unless addressed early with robust, well-designed screening and profiling strategies.

Creative Biogene provides integrated kinase screening and profiling services built to support informed decision-making from hit identification through lead optimization.

Figure 1. ATP-dependent phosphorylation regulating protein activity. (Bajusz D, et al., 2017)

Designed for the Complexity of the Kinome

Traditional single-target screening is no longer sufficient for kinase programs. Successful development depends on understanding:

Potency and selectivity across kinase families
Biochemical inhibition versus cellular functional response
ATP-competitive effects versus pathway-level modulation
On-target efficacy balanced against off-target risk

A Versatile Assay Platform from Enzyme to Cell

Creative Biogene's kinase platforms are engineered to meet these challenges, combining biochemical precision with cellular relevance to generate data that directly informs medicinal chemistry and downstream development. Based on an extensive portfolio of validated kinase assays, Creative Biogene supports kinase programs at every discovery stage:

Kinase Screening and Profiling with Biochemical Assays

High-sensitivity enzymatic assays for potency, kinetics, and selectivity profiling.

Kinase Screening & Profiling with Cellular Assays

Cell-based functional assays to confirm pathway engagement and translational relevance.

Supporting Selectivity-Driven Kinase Drug Discovery

With dozens of kinase inhibitors approved and many more in development, it is now widely recognized that selectivity is contextual, not absolute. Effective kinase drugs often rely on well-characterized selectivity profiles rather than single-target exclusivity.

Creative Biogene's profiling strategies are designed to support this reality by enabling:

Early identification of off-target kinase liabilities
Rational prioritization of lead series
Informed trade-offs between potency, selectivity, and cellular activity

This approach helps minimize late-stage failures while accelerating confident progression.

Enabling Kinase Biology

To support deeper mechanistic and translational studies, Creative Biogene also offers a comprehensive portfolio of kinase gene-related research tools, including:

Stable kinase-expressing cell lines
Premade viral particles
Recombinant proteins and cell lysates
Cloning services and RNAi products

These resources allow seamless expansion from compound screening into target validation, pathway dissection, and functional biology studies.

Extensive Kinase Target Coverage

Our services support a wide range of clinically relevant kinases and fusion targets. Custom targets and tailored panels are available upon request.

Differentiated by Execution, Not Just Technology

What sets Creative Biogene apart is not a single assay format, but a well-integrated execution model. We do not simply generate data—we help you interpret it in the context of drugability, selectivity risk, and development feasibility

Expert Team

Experienced kinase scientists providing hands-on drug discovery support.

Tailored Assays

Flexible designs customized for target class, mechanism, and program stage.

Comprehensive Coverage

Broad kinase panels supporting both focused and wide-scale profiling.

Your Partner for Actionable Kinase Screening

Kinase drug discovery requires more than assay availability. It demands strategy, reliable execution, and confidence in the data guiding each decision. Creative Biogene delivers screening and profiling solutions designed to help you progress efficiently, with clarity and control. Explore our specialized services or contact Creative Biogene to discuss a kinase screening strategy aligned with your scientific and development goals.

* For research use only. Not intended for any clinical use.

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AGAP3-BRAF	EML4	ETV6-KDR	FLT3	MPL	RELA-BTK
AGK-BRAF	EML4-ALK	ETV6-NTRK2	FLT3-ITD	NRAS	RELA-BTK
AXL	EPOR	ETV6-NTRK3	GOPC-ROS1	NTRK1	RET
BCR-ABL	EPOR-JAK2	ETV6-PDGFRB	IGF1R	NTRK2	ROR1
BCR-FGFR1	ERBB2	ETV6-SYK	JAK2	NTRK3	ROR2
BRAF	ERBB3	FCGR2A	KDR	p95HER2	SLC34A2-ROS1
BTK	ETV6-AXL	FGFR1-TACC1	KIF5B-RET	PDGFRA	ST2-T2A
CCDC6-RET	ETV6-BTK	FGFR2	KIT	PIK3CA	TEK
CD47-ROS1	ETV6-FGFR4	FGFR2-BICC1	KRAS	PIK3CB	TIE1
CSF1R	ETV6-IGF1R	FGFR3-BAIAP2L1	LMNA-NTRK1	PIM1-L	TMEM87B-MERTK
CSF3R	ETV6-JAK1	FGFR3-TACC3	MAD1L1-BRAF	PIM1-S	TPR-MET
EGFR	ETV6-JAK2	FGFR4	MERTK	PLAUR
EGFR-ERBB3	ETV6-JAK3	FIP1L1-PDGFRA	MET	RBM6-CSF1R