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Fig.1 Schematic outline of LAM PCR.
Viral vectors have been successfully used in clinical gene therapy to obtain stable expression of the transgene and therefore long-term correction of the disease. However, the integration of viral vectors at certain genomic locations can not only alter gene expression but also can lead to various side-effects, such as insertional activation of proto-oncogenes, uncontrolled clonal proliferation or the generation of new gene isoforms. Therefore, the analysis of viral vector integration site (IS) in target cells is of vital importance to illuminate and ensure the safety of the therapeutic vector system. Creative Biogene, as one of the leading biotechnology company in the world, has extensive expertise and experience which can offer three different technologies to help you analyze the viral vector insertion/integration sites. Characteristics of the three different technologies is shown below. You can choose the analysis method that works best for you based on your needs.
Creative Biogene is a US-based manufacturer and provider of genomics and proteomics products and services for academic and governmental research institutes, pharmaceutical and biotechnology industry.