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LncRNA qPCR primer set


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LncRNA qPCR primer set

Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs that is more than 200 base pairs lacking significant open reading frames and do not encode for proteins. Many identified lncRNAs are transcribed by RNA polymerase II (RNA pol II) and are polyadenylated. In recent years, extensive efforts to get deeper understanding of lncRNA biology have yielded evidence of their diverse structural and regulatory roles in protecting chromosome integrity, maintaining genomic architecture, X chromosome inactivation, imprinting, transcription, translation and epigenetic regulation. Furthermore, accumulating reports of lncRNA expression across numerous cancer types suggest that aberrant lncRNA expression may be a major contributor to tumorigenesis. Due to these characteristics, lncRNA may be superior therapeutic targets than existing protein coding genes for various diseases. Additionally, lncRNAs act themselves as a functional molecule and their expression may be a better indicator of disease states.

1-1 LncRNA-qPCR-primer-set.jpg

Fig.1 Models of lncRNA functions. [1]

Creative Biogene, as one of the leading biotechnology company in the world, has the expertise and ability to provide you high-quality lncRNA qPCR primer set products to accelerate your lncRNA research. Creative Biogene’s qPCR primer sets are designed under the same parameters and requirements, ready-to-use, gene specific and sensitive quantification assays for qPCR applications, available at very competitive prices. Our lncRNA qPCR primer sets containing validated reverse and forward qPCR primer in a flexible format which allows you to choose the one that best match your specific needs. Just provide us with the species and gene name you are interested in, we will offer you the high-quality and efficient tool to help you with your lncRNA research.

References:

  1. Morlando M, Ballarino M & Fatica A. (2015). Long non-coding RNAs: new players in hematopoiesis and leukemia.Frontiers in medicine, 2, 23.
  2. Bhat SA., et al. (2016). Long non-coding RNAs: Mechanism of action and functional utility. Non-coding RNA research, 1(1), 43-50.
  3. Khorkova O, Hsiao J & Wahlestedt C. (2015). Basic biology and therapeutic implications of lncRNA. Advanced drug delivery reviews, 87, 15-24.

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