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Delivery System in Gene Therapy

Creative Biogene, as a global provider, offers various gene delivery systems to assist customers for genetic research and application. Our services begin with free consultation, while end with required final products and reliable reports. At Creative Biogene, our scientists are experienced in viral vectors and non-viral methods for gene delivery.

Gene therapy, which delivers nucleic acid reagent into cells to alter function in entire organism, is a promising therapeutic method for cancer and genetic diseases. The success of gene therapy mostly depends on delivery enough therapeutic reagents to the correct target sites to achieve the desired level of therapeutic effects. The ideal situation is to deliver genetic materials into cells in a safe and high-efficient way, and then to make it work. There are two major classes of methods, viral and non-viral.

Delivery System in Gene TherapyFig 1. Gene delivery vectors1

Viral Vectors

All viruses bind to their hosts and introduce their genetic material into the host cell as part of their replication cycle. However, only lysogenic viruses, which do not kill cells quickly, have possibility to be modified as a vector. To be a transfer vector, viruses are required to be engineered for decreasing the risk of virus-associated toxicity. After modification, retroviruses, adenoviruses, even herpes simplex virus are potential vectors for gene delivery. The viral vectors can be divided into two types: integrating and non-integrating viral vectors. Both viral vectors can efficiently transfer genetic material into cells.

Delivery System in Gene TherapyFig 1. Viral vectors for gene therapy3

Creative Biogene offers multi-type viral vector services for gene delivery, including but not limited to:

  • Retroviruses
  • Adenoviruses
  • Herpes Simplex Virus
  • Lentivirus
  • Adeno-associated Virus

Non-Viral Methods

Viruses efficiently delivers genetic material into cells, but have some limitations. Non-viral methods, as the other classes of gene delivery, present certain advantages over viral methods with simple large-scale production and low host immunogenicity.

Non-viral vectors, which include naked-DNA and liposomes, mostly are based on plasmids. Comparing with viral vectors, non-viral vectors are considered safer and cheaper, and have almost no limitation in therapeutic gene size. Genetic materials can be delivered in different forms by non-viral methods, including injection of naked DNA, liposomes and particle-mediated gene transfer.

Creative Biogene provides various non-viral vectors for customers, especially liposomes. Custom development of non-viral vectors is welcome as well.

For more information, please feel free to contact us at info@creative-biogene.com or 1-631-626-9181.

Related Service

Liposomes in Gene Therapy

References:

  1. Dan Wang, et al. ’State-of-the-art human gene therapy: Part I. Gene delivery technologies’, Discov Med., 2014 Jul-Aug; 67-77
  2. Shrikant Mali, ‘Delivery systems for gene therapy’, Indian J Hum Genet, 2013 Jan-Mar; 19(1):3-8
  3. Teresa Borras, ‘The pathway from genes to gene therapy in Glaucoma: a review of possibilities for using genes as Glaucoma Drugs’, Asia Pac J Ophthalmol (Phila), 2017 Jan-Feb: 6(1): 80-93

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