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Custom Viral Service

Brief Introduction

Creative Biogene provides world-class packaging services for a variety of viral types using our QVirusTM platform. Creative Biogene's state-of-the-art facilities and highly experienced staff are available in order to assist in all areas of virus vector design and construction, as well as the generation of the virus in a quick turnaround. Our custom viral services are highlighted by a consistent high titer and large delivery viral counts.

Custom Viral Service

Viral vectors are a tool commonly used by molecular biologists to deliver genetic material into cells. This process can be performed inside a living organism (in vivo) or in cell culture (in vitro). Though a number of viruses have been developed, interest has centered on four types: retrovirus, lentivirus, adenovirus and adeno-associated virus (AAV).

Comparison of adenovirus, AAV, retrovirus and lentivirus for gene delivery

FeaturesAdenovirus AAV Lentivirus Retrovirus
Genome dsDNA ssDNA ssRNA ssRNA
Infect Dividing Cells Yes Yes Yes Yes
Infect Non-dividing Cells Yes Yes Yes No
Genomic Integration No Yes/No Yes/No Yes
Expression Pattern 10 days to months 2.5–6.0 months >12 months Days to months
Expression Level High Moderate Moderate Moderate
Cloning Capacity 8-30 kb 3.5–4.0 kb 7–8 kb 7–8 kb
Immune Response High Very low Low Moderate
Viral Titer High Moderate Moderate Moderate
Transduction Efficiency High Moderate Moderate Moderate

Features of Creative Biogene's viral packaging services

  • Quality: Production of virus in a state-of-the art BSL-2 facility with robust quality control in accordance with NIH Biosafety Level 2 criteria.
  • High Titer: Using proprietary technologies that are unique and highly efficient, we can easily yield 108 to 109 TU/ml lentivirus/retrovirus without concentrating steps.
  • Quick Turnaround: Creative Biogene has consolidated its procedure of viral packaging services as a standard production-line resulting in a quick turnaround.
  • Service Customization: We will do anything in our power to make sure your needs are met. We offer plasmid amplification, custom vector building, and large scale production.
For research use only. Not intended for any clinical use.

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