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- Transfected Stable Cell Lines
  
  Reliable | High-Performance | Wide Rage
  
  Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
  
  Transfected Stable Cell Lines
- Premade Virus Particles
  
  Ready-to-Use | High Titer | Versatile Applications
  
  Premade AAV, adenovirus, lentivirus particles, safe, stable, in stock.
  
  Premade Virus Particles
- Virus-Like Particles (VLPs)
  
  Stable | Scalable | Customizable
  
  Advanced VLPs for vaccine development (Chikungunya, Dengue, SARS-CoV-2), gene therapy (AAV1 & AAV9), and drug screening (SSTR2, CCR5).
  
  Virus-Like Particles (VLPs)
- Oligonucleotide Products
  
  Precise | High Yield | Tailored Solutions
  
  Accelerate your research with cost-effective LncRNA qPCR Array Technology.
  
  Oligonucleotide Products
- RNA Interference Products
  
  Targeted | Potent | High Specificity
  
  Human Druggable Genome siRNA Library enables efficient drug target screening.
  
  RNA Interference Products
  - shRNA Clones
  - siRNA Libraries
- Recombinant Drug Target Proteins
  
  Authentic | Versatile | Accelerated
  
  Providing functional, high-purity recombinant proteins—including membrane proteins and nanodiscs—to overcome bottlenecks in drug screening and target validation.
  
  Recombinant Drug Target Proteins
  - Nanodiscs
- Clones
  
  Validated | Reliable | Comprehensive Collection
  
  Ready-to-use clones for streamlined research and development.
  
  Clones
- Kits
  
  Complete | Convenient | High Sensitivity
  
  Chromogenic LAL Endotoxin Assay Kit ensures precise, FDA-compliant endotoxin quantification for biosafety testing.
  
  Kits
- Enzymes
  
  Purified | Stable | Efficient
  
  Powerful Tn5 Transposase for DNA insertion and random library construction.
  
  Enzymes
  - Modified Enzyme
  - Restriction Enzyme
- Aptamers
  
  Highly Specific | Robust | Versatile
  
  Aptamers for key proteins like ACVR1A, Akt, EGFR, and VEGFR.
  
  Aptamers
- Adjuvants
  
  Enhancing | Synergistic | Effective
  
  Enhance immune responses with high-purity, potent CpG ODNs.
  
  Adjuvants
- Laboratory Equipment
  
  Innovative | Reliable | High-Precision
  
  Effortlessly streamline DNA extraction with CB™ Magnetic-Nanoparticle Systems.
  
  Laboratory Equipment
Services
- Stable Cell Line Generation
  
  Reliable | Scalable | Customizable
  
  Fast proposals, regular updates, and detailed reports; strict quality control, and contamination-free cells; knockout results in 4-6 weeks.
  
  Stable Cell Line Generation
- Target-based Drug Discovery Service
  
  Innovative | Comprehensive | Efficient
  
  Target identification, validation, and screening for drug discovery and therapeutic development.
  
  Target-based Drug Discovery Service
- Custom Viral Service
  
  Versatile | High-Yield | Safe
  
  Unbeatable pricing, fully customizable viral packaging services (covering 30,000+ human genes, 200+ mammals, 50+ protein tags).
  
  Custom Viral Service
- Custom Antibody Service
  
  Precise | Flexible | Efficient
  
  End-to-end antibody development support, from target to validation, enabling clients to rapidly obtain application-ready antibodies.
  
  Custom Antibody Service
- Antibody-Drug Conjugation Service
  
  Integrated | Controlled | Translational
  
  Comprehensive solutions covering design, development, and validation to ensure conjugated drugs with consistent quality and clinical potential.
  
  Antilbody-drug Conjugation Service
- Protein Degrader Service
  
  Efficient | High-Precision | Advanced Therapeutics
  
  Harness the power of protein degraders for precise protein degradation, expanding druggable targets and enhancing therapeutic effectiveness for cutting-edge drug discovery.
  
  Protein Degrader Service
- Nucleotides Service
  
  Accurate | Flexible | High-Quality
  
  Custom synthesis of oligonucleotides, primers, and probes for gene editing, PCR, and RNA studies.
  
  Nucleotides Service
- Custom RNA Service
  
  Custom RNA ServicePrecise | Flexible | GMP-ReadyCustom
  
  RNA design, synthesis, and manufacturing—covering mRNA, saRNA, circRNA, and RNAi. Fast turnaround, rigorous QC, and seamless transition from research to GMP production.
  
  Custom RNA Service
- Custom Libraries Construction Service
  
  Comprehensive | High-throughput | Accurate
  
  Custom cDNA, genomic, and mutagenesis libraries for drug discovery, screening, and functional genomics.
  
  Custom Libraries Construction Service
- Gene Editing Services
  
  Precise | Efficient | Targeted
  
  Gene editing solutions for gene editing, knockouts, knock-ins, and customized genetic modifications. Integrated multi-platform solutions for one-stop CRISPR sgRNA library synthesis and gene screening services
  
  Gene Editing Services
- Microbe Genome Editing Service
  
  Precise | Scalable | Customizable
  
  Enhance microbial productivity with advanced genome editing using Rec-mediated recombination and CRISPR/Cas9 technologies.
  
  Microbe Genome Editing Service
  - CRISPR Based Microbe Genome Editing Service
  - Recombineering Based Microbe Genome Editing Service
- Biosafety Testing Service
  
  Reliable | Comprehensive | Regulated
  
  Complete biosafety testing solutions for gene therapy, viral vectors, and biologics development.
  
  Biosafety Testing Service
- Plant Genetic Modification Service
  
  Advanced | Sustainable | Tailored
  
  Genetic modification for crop improvement, biotechnology, and plant-based research solutions.
  
  Plant Genetic Modification Service
- Plant-based Protein Production Service
  
  Efficient | Scalable | Customizable
  
  Plant-based protein expression systems for biopharmaceuticals, enzyme production, and research.
  
  Plant-based Protein Production Service
  - Plant Cell Suspension-based Protein Production
  - Rice Endosperm-Specific Expression System
- Aptamers Service
  
  Innovative | Fast | Cost-Effective
  
  Revolutionizing drug delivery and diagnostic development with next-generation high-throughput aptamer selection and synthesis technologies.
  
  Aptamers Service
  - Aptamers Services
  - Technology Platforms
Applications
- CGT Biosafety Testing
  
  Comprehensive | Accurate | Regulatory-compliant
  
  Internationally certified evaluation system for biologics, gene therapies, nucleic acid drugs, and vaccines.
  
  CGT Biosafety Testing
- Pandemic Detection Solutions
  
  Rapid | Precise | Scalable
  
  Balancing accuracy, accessibility, affordability, and rapid detection to safeguard public health and strengthen global response to infectious diseases.
  
  Pandemic Detection Solutions
CDMO
- cGMP Cell Line Development
  
  Reliable | Scalable | Industry-leading
  
  Stable expression over 15 generations with rapid cell line development in just 3 months.
  Supports adherent and suspension cell lines, offering MCB, WCB, and PCB establishment.
  
  cGMP Cell Line Development
- GMP mRNA Production
  
  Efficient | Scalable | Precise
  
  Scalable mRNA production from milligrams to grams, with personalized process design for sequence optimization, cap selection, and nucleotide modifications, all in one service.
  
  GMP mRNA Production
- GMP Plasmid Production
  
  High Quality | Scalable | Regulatory-compliant
  
  Our plasmid production services span Non-GMP, GMP-Like, and GMP-Grade levels, with specialized options for linearized plasmids.
  
  GMP Plasmid Production
- GMP Viral Vector Manufacturing
  
  Scalable | High Yield | Quality-driven
  
  Advanced platforms for AAV, adenovirus, lentivirus, and retrovirus production, with strict adherence to GMP guidelines and robust quality control.
  
  GMP Viral Vector Manufacturing
AI
- AI-Driven Gene Editing and Therapy
  
  Innovative | Precision | Transformative
  
  AI-powered one-click design for customized CRISPR gene editing strategy development.
  
  AI-Driven Gene Editing and Therapy
- AI-Antibody Engineering Fusion
  
  Next-Generation | Targeted | Efficient
  
  AI and ML algorithms accelerate antibody screening and predict new structures, unlocking unprecedented possibilities in antibody engineering.
  
  AI-Antibody Engineering Fusion
- AI-Driven Enzyme Engineering
  
  Smart | Efficient | Tailored
  
  High-throughput enzyme activity testing with proprietary datasets and deep learning models for standardized and precise enzyme engineering design.
  
  AI-Driven Enzyme Engineering
- AI-Enhanced Small Molecule Screening
  
  Predictive | Efficient | Insightful
  
  Leverage AI to uncover hidden high-potential small molecules, prioritize leads intelligently, and reduce costly trial-and-error in early drug discovery.
  
  AI-Enhanced Small Molecule Screening
- AI-Driven Protein Degrader Drug Development
  
  Innovative | Targeted | Accelerated
  
  Use AI-guided design to optimize protein degraders, addressing design complexity and enhancing efficacy while shortening development timelines.
  
  AI-Driven Protein Degrader Drug Development
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Custom RNA Service

RNA ResearchRNA In Vitro SynthesisOligonucleotide SynthesisOne-Stop RNA CDMOAdvantagesContact Us

In rapidly evolving RNA research and application landscape, RNA has become a vital bridge connecting basic science with clinical translation—from non-coding RNA functional studies to mRNA vaccine development, and the rise of novel circRNA and saRNA technologies.

As a scientist-founded and scientist-driven company, Creative Biogene is dedicated to transforming cutting-edge scientific discoveries into industry-grade tools and service capabilities.

Our Principles:

Comprehensive technical support from experimental design to data analysis
Rigorous quality control ensuring batch-to-batch consistency and regulatory compliance
Modular service design tailored to specific targets and disease areas

Comprehensive customized RNA solutions

Empowering every step from basic research to drug development.

Gene Synthesis

High-precision platform enabling accurate gene synthesis and editing for diverse RNA constructs.

RNA Engineering

Comprehensive RNA construction and modification technologies ensuring stability, functionality, and translational efficiency.

Delivery Optimization

Tailored vector and delivery systems maximizing expression and therapeutic performance across applications.

RNA Research

Deciphering RNA regulatory mechanisms for functional discovery and molecular intervention

RNA plays a central role in gene regulation and serves as a key entry point for molecular medicine research. Creative Biogene provides comprehensive research services encompassing miRNA and circRNA, enabling scientists to efficiently explore the functional properties and regulatory networks of these RNA molecules.

miRNA Service

Precise sequence design and expression profiling to uncover miRNA involvement in gene regulation, signaling pathways, and disease progression.

circRNA Service

A robust platform supporting circularization optimization, structural validation, and mechanistic studies through advanced circular RNA synthesis and functional analysis.

With extensive project experience and a well-established quality management system, Creative Biogene provides highly reliable data support for small RNA research across diverse fields.

RNA Expression Profiling

miRNA Expression Profiling

Custom miRNA Microarray

circRNA Sequencing

circRNA Microarray

Functional Characterization

Functional miRNA Screening

Agomir/ Antagomir Synthesis

circRNA Functional Analysis

Interaction Analysis

MicroRNA Sponge

circRNA-miRNA/RBP Interaction Analysis

mRNA Self-amplifying RNA Circular RNA dsRNA tRNA Aminoacyl-tRNA

RNA In Vitro Synthesis

Accurate, efficient, and customizable In vitro RNA synthesis services

High-fidelity and high-purity synthesis is the cornerstone of RNA applications. Through our advanced in vitro transcription and modification systems, Creative Biogene offers high-quality custom synthesis services for a wide range of RNA types.

Our platform supports:

Flexible production scale: From microgram to gram-level synthesis, meeting both research and drug development needs.
Extensive modification capacity: Over 200 modification options and high substitution efficiency, suitable for diverse structural and functional optimization.
High purity and integrity: Purity up to 95%, molecular weight deviation ≤0.05%, ensuring experimental stability and reproducibility.
Research- to GMP-grade scalability: Seamless transition between research-grade and GMP-grade production for smooth translation from discovery to clinical stages.

Understanding that RNA stability, immunogenicity, and translational efficiency are critical for functional applications, the Creative Biogene team ensures every RNA molecule meets both scientific and application-driven performance standards through process optimization and stringent QC.

Oligonucleotide Synthesis

High-precision oligonucleotide synthesis empowering RNAi and gene regulation studies

RNA interference (RNAi) has become a key approach in studying gene function and developing therapeutic strategies. Creative Biogene provides chemically synthesized and modification-optimized RNAi Oligonucleotide Synthesis services.

AI-assisted sequence design for enhanced silencing efficiency and specificity

Automated high-throughput solid-phase synthesis ensuring batch consistency and high purity

Broad modification options and fluorescent labeling

ISO 13485-certified quality system compliant with molecular diagnostic and drug development standards.

Our RNAi services support not only fundamental research but also drug screening and functional validation, providing ready-to-use molecular tools for translational applications.

RNAi

Gene Editing

Probes & Sequencing

Modified Nucleic Acids

GMP mRNA CDMO Service

GMP circRNA CDMO Services

GMP-saRNA CDMO Service

One-Stop RNA CDMO

Full-spectrum support from research to pharmaceutical manufacturing

In response to the rapid growth of the RNA therapeutics industry, Creative Biogene has developed a one-stop CDMO platform for mRNA, saRNA, and circRNA drug development, integrating expertise in gene synthesis and RNA engineering. We offer comprehensive support from sequence design and in vitro transcription to GMP-grade production and analytical validation.

End-to-end manufacturing workflow: Fully traceable from sequence optimization, template preparation, RNA synthesis, purification, to formulation development.
LNP encapsulation technology: Enables multi-component co-encapsulation for diverse therapeutic delivery needs.
GMP-grade quality system: Fully compliant with ICH and ISO standards to support regulatory filing and clinical submissions.
Comprehensive analytical services: Assessment of mRNA integrity, capping efficiency, residual impurities, and LNP encapsulation rate.

From vaccines and cancer immunotherapies to rare disease drug development, Creative Biogene provides scientifically rigorous, production-ready RNA solutions with high reliability and traceability.

Why Choose Creative Biogene?

Discover the advantages of partnering with our expert team for your RNA research and development needs

End-to-end service coverage: From molecular design to GMP production, establishing a complete RNA technology ecosystem.
Scientist-driven team: Experts from molecular biology, RNA chemistry, and pharmaceutical development with extensive project experience.
Quality and compliance assurance: Strict adherence to international QC standards, ensuring product purity and consistency.
Flexible customization: Tailor-made project solutions designed to meet specific research goals and experimental conditions.

Empowering RNA Innovation

Creative Biogene is driven by science and committed to innovation. Through the Custom RNA Service, we strive to be a trusted global partner in RNA research and application, providing continuous support for customers along the path from basic discovery to therapeutic development and industrial translation.

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