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| General Information | |
| Organism | Mus musculus, mouse |
| Cell Line Description | In 1941, scientists isolated C1498 cells from 10-month-old female C57BL/6 mice suffering from leukemia and injected them intravenously into syngeneic mice, causing them to suffer from acute leukemia. C1498 cells have always been a model for acute leukemia. There are many documents documenting the effects of highly proliferating C1498 cells injected into susceptible mice via intravenous, subcutaneous or peritoneal routes on hematopoietic organs such as blood, spleen and lymph nodes, as well as non-hematopoietic organs such as ovaries and kidneys. Earlier studies suggested that mouse models induce granulocytic leukemia or myelomonocytic leukemia. C1498 is a mouse leukemia cell line that can be used as an acute myeloid leukemia model. It has few cell surface hematopoietic markers and inhibits the hematopoietic function of normal mice by secreting soluble cytokines. C1498 cells express low levels of programmed cell death-ligand 1 (PD-L1) in the culture medium, but the expression of PD-L1 is significantly upregulated in vivo. |
| Disease | Acute myeloid leukemia |
| Morphology | Lymphoblast |
| Gender | Female |
| Product Format | Frozen |
| Growth Mode | Suspension |
| Biosafety Level | 1 Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Applications | 1. Study of hematologic malignancies 2. Studying the molecular mechanisms of leukemia 3. Testing potential cancer treatments 4. Studying the interaction between leukemia cells and the immune system 5. Assessing the efficacy of new treatments in preclinical studies |
| Shipped In | Dry ice |
| Storage Temperature | −196°C |
| Additional Info | In 2016, a study pointed out that after injecting C1498 cells into mice, many of the leukemia characteristics observed were the same as human acute myelomonocytic leukemia. Invading leukemia cells result in a depletion of mature and immature progenitor cells and precursor bone marrow hematopoietic cells, and C1498 cells are found at higher rates in the peripheral blood. |
| Characteristics | |
| Strain | C57BL/6J |
| Antigen Expression | The cells do not express B7-1. |
| Mycoplasma Test | Negative |
| Culture Conditions and Handling | |
| Subculturing | Cultures can be maintained by adding fresh medium or changing the medium. Alternatively, cultures can be established by centrifugation and then resuspended in fresh medium at a concentration of 1 to 3 x 105 viable cells/mL. Saturated densities of 1 to 2 x 106 are available. |
| Medium Renewal | Every 2 to 3 days |
| Culture Medium | Dulbecco's Modified Eagle's Medium (DMEM) modified to contain 2 mM L-glutamine, 4500 mg/L glucose and 10% of fetal bovine serum. |
| Culture Conditions | Atmosphere: Air, 95%; CO2, 5%;Temperature: 37°C |
| Cryopreservation | 95% FBS + 5% DMSO (Dimethyl sulfoxide) |
The above is only part of a part of cell line products. If you don't find the cell line you want, Creative Biogene can also provide stable cell line generation service with the best prices and fastest turnaround time for you! Contact us for more information or to request a quote.
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