Linearized Plasmid GMP Production
With the development of vaccines and therapeutics based on mRNA technology, the demand for production from template plasmids to mRNA has increased. Template plasmid preparation, plasmid linearization, quality testing and release of plasmids are important parts of mRNA raw material reagent production. Creative Biogene has developed a complete, proven GMP-compliant linearization plasmid production platform to provide customers with one-stop linearization plasmid production services to meet clinical needs pending commercial production.

Plasmid Linearization Services at Creative Biogene
Creative Biogene's linearized plasmid GMP platform has an experienced research team and has developed a proven manufacturing process. In addition, we offer a wide range of linearized enzymes to provide our clients with flexible development services.
Creative Biogene's linearized plasmid GMP production services include the following:
- One-stop plasmid production and manufacturing services from preclinical to large-scale process production.
- Linearization of existing plasmids according to customer requirements.
- Providing complete upstream and downstream process development and optimization services for plasmid manufacturing projects to meet customer demand for plasmid yield.
Production Process of Linearized Plasmids
Creative Biogene combines our proven linearization plasmid platform with our extensive expertise to provide a proven one-stop process for linearization plasmid production. Our dedicated researchers can provide customized services at any of the following development stages.

Unique Advantages of Linearized Plasmids
- High yield strain screening
- mRNA linearization rate >95%
- polyA loss rate<5%
- polyA length up to 120bp
What We Deliver
| Linearized Plasmid GMP Production |
| Linearized plasmid sample | √ |
| CoA | √ |
| Production report | √ |
| TSE/BSE statement | √ |
As a trusted CDMO partner, Creative Biogene can provide high quality, competitive linearized plasmid GMP production services to accelerate the progress of our clients' projects at different stages of development. Please feel free to contact us if you have a need, and our experienced specialists will be happy to assist you.
* For research use only. Not intended for any clinical use.